1. New understanding of the pathogenesis and treatment of stroke-related sarcopenia
- Author
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Tao Yue, Wei Li, and Yanming Liu
- Subjects
0301 basic medicine ,Clinical tests ,medicine.medical_specialty ,Sarcopenia ,medicine.medical_treatment ,Pathogenesis ,RM1-950 ,Assessment ,Muscle mass ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,medicine ,Humans ,cardiovascular diseases ,Muscle Strength ,Muscle, Skeletal ,Stroke ,Stroke-related sarcopenia ,Pharmacology ,Denervation ,Motor Neurons ,Rehabilitation ,business.industry ,Nutritional Support ,Stroke Rehabilitation ,General Medicine ,medicine.disease ,musculoskeletal system ,body regions ,Treatment ,030104 developmental biology ,Rehabilitation exercise ,030220 oncology & carcinogenesis ,Therapeutics. Pharmacology ,business ,human activities - Abstract
Sarcopenia is a syndrome characterized by progressive systemic muscle loss and decreased function. The loss of systemic muscle mass and decreased function after stroke can't be explained by brain injury alone, and it is considered to be a kind of secondary sarcopenia, which is called stroke-related sarcopenia. More and more evidence shows that stroke-related sarcopenia can promote the occurrence and development of sarcopenia through a variety of pathogenesis, such as immobilization, impaired feeding, sympathetic activation, inflammation and denervation. Post-stroke disability brings difficulties to the screening and diagnosis of sarcopenia. Simple and easy rehabilitation scores and clinical tests can be used for the determination of body function under specific conditions of stroke, as well as for the screening stroke-related sarcopenia. At present, there is still no particularly effective way to stop its progress,however, the combination of rehabilitation exercise, nutrition supply and drugs may delay or even prevent the development of stroke-related sarcopenia. This article reviews the latest progress in the pathogenesis, screening, evaluation and treatment of stroke-related sarcopenia to provide reference for clinical treatment and rehabilitation of stroke.
- Published
- 2020