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Aspirin is one of the most widely used medications globally as an analgesic and antipyretic drug. Aspirin use as an antiparasitic against fish parasites has never been tested. The parasite Dactylogyrus is considered a serious threat to freshwater aquaculture in relation to considerable losses. The present study is aimed to evaluate the antiparasitic effect of aspirin against Dactylogyrus extensus on Cyprinus carpio and alteration in gill histopathology. In vitro, aspirin exhibited antiparasitic activity with median effective concentration (EC50) values at one and six minutes of 8.137 g/L−1 and 1.629 g/L−1, were assessed for the first time. In vivo antiparasitic efficacy of aspirin to D. extensus was found to be 46.49%. Severe lesion profile was observed in histopathological evaluations of the gills. [ABSTRACT FROM AUTHOR]