1. Reye's syndrome developing in an infant on treatment of Kawasaki syndrome.
- Author
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Wei CM, Chen HL, Lee PI, Chen CM, Ma CY, and Hwu WL
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Aspirin administration & dosage, Humans, Infant, Male, Mucocutaneous Lymph Node Syndrome complications, Reye Syndrome physiopathology, Taiwan, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Aspirin adverse effects, Mucocutaneous Lymph Node Syndrome drug therapy, Reye Syndrome etiology
- Abstract
Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to > 100 mg/kg per day), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10-month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.
- Published
- 2005
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