1. Special scenarios in the management of central nervous system aspergillosis: a case series and review of literature.
- Author
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Ray S, Balaini N, Chakravarty K, Pattanayak S, Goel A, Takkar A, and Lal V
- Subjects
- Adult, Aspergillus drug effects, Brain microbiology, Brain pathology, Databases, Factual, Disease Management, Follow-Up Studies, Humans, Immunocompromised Host, Male, Neuroaspergillosis epidemiology, Retrospective Studies, Risk Assessment, Sampling Studies, Severity of Illness Index, Treatment Outcome, Antifungal Agents therapeutic use, Aspergillus pathogenicity, Brain diagnostic imaging, Magnetic Resonance Imaging methods, Neuroaspergillosis diagnosis, Neuroaspergillosis drug therapy
- Abstract
Aspergillus is a rare but important opportunistic pathogen to invade the central nervous system (CNS). It is a significant pathogen of not only immunocompromised but also immunocompetent patients. Its manifestations are pleiotropic, reflecting multiple mechanisms of pathogenesis and host interactions. Despite significant advances in diagnostic methods and therapeutic options, the mortality remains high. Several advances have been made in medications and surgical management, yet, current treatment practices lack uniformity. Patient woes are further heightened by the high costs of treatment and prolonged duration of therapy. In view of the challenging aspects of this disease, we present a short review of four challenging cases touching on the varied aspects of management of CNS aspergillosis covering pathogenesis, diagnostic pitfalls, surgical and medical options and evidence-based guidelines for the management of the same., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2019
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