1. Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus.
- Author
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Shen L, Zhu L, Luo Q, Li XW, Xi JQ, Kong GM, and Song YC
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Aspergillus isolation & purification, Cell Line, Tumor, Cell Survival drug effects, Endophytes isolation & purification, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Aspergillus chemistry, Endophytes chemistry, Ergot Alkaloids chemistry, Ergot Alkaloids isolation & purification, Oryza microbiology
- Abstract
The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent., (Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)
- Published
- 2015
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