1. Successful Antifungal Combination Therapy and Surgical Approach for Aspergillus fumigatus Suppurative Thyroiditis Associated with Thyrotoxicosis and Review of Published Reports.
- Author
-
Nicolè S, Lanzafame M, Cazzadori A, Vincenzi M, Mangani F, Colato C, El Dalati G, Brazzarola P, and Concia E
- Subjects
- Aged, Aspergillosis diagnosis, Aspergillus fumigatus isolation & purification, Caspofungin, Cryoglobulinemia complications, Cryoglobulinemia diagnosis, Echinocandins administration & dosage, Humans, Immunocompromised Host, Invasive Fungal Infections complications, Invasive Fungal Infections diagnosis, Invasive Fungal Infections drug therapy, Invasive Fungal Infections surgery, Lipopeptides administration & dosage, Male, Thyroiditis, Suppurative complications, Thyroiditis, Suppurative diagnosis, Thyrotoxicosis complications, Thyrotoxicosis diagnosis, Thyrotoxicosis surgery, Treatment Outcome, Voriconazole administration & dosage, Antifungal Agents administration & dosage, Aspergillosis drug therapy, Aspergillosis surgery, Drug Therapy, Combination methods, Thyroidectomy, Thyroiditis, Suppurative drug therapy, Thyroiditis, Suppurative surgery
- Abstract
In immunocompromised patients, Aspergillus infections are important causes of morbidity and mortality. We describe a patient with cryoglobulinemic vasculitis who developed disseminated invasive aspergillosis with thyrotoxicosis caused by Aspergillus fumigatus. The diagnosis was based upon radiological, microbiological and pathological findings. The patient was treated successfully with voriconazole and caspofungin treatment followed by total thyroidectomy. We provide an overview of published reports on Aspergillus thyroiditis with an emphasis on therapeutic approaches.
- Published
- 2017
- Full Text
- View/download PDF