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Case Report: An adolescent admitted to hospital because of an obvious convulsion seizure presented with a high level of serum macroaspartate aminotransferase. This macroaspartate aminotransferase was discovered by chance when blood tests were made., Discussion: Macroaspartate aminotransferase is a persistent, benign phenomenon, probably not congenital, discovered either in healthy patients, or in adults suffering from malignancies or autoimmune diseases. Macroenzymes have been identified as a cause of benign increase in a number of serum enzymes, like macroamylase serum levels. The macroenzyme is often an immunoglobulin G-complexed enzyme., Conclusion: It is important for clinicians to be aware of their existence in order to avoid unnecessary procedures. It is important that the patient is informed of the macroaspartate aminotransferase and that the same is stated in his health record.