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Background: We investigated type I endometrioid uterine cancer in US-born Asians versus immigrant Asians. Methods: Data was obtained from the National Cancer Institute from 2001 to 2009. Chi squared, t-test, and binomial regression methods were used for statistical analyses. Findings: Of 4834 Asians with uterine cancer, 62% were born in the USA and 38% were immigrants. 2972 (61%) had type I uterine cancer (grade 1 or 2, endometrioid histology) and the remaining women had type II disease. Compared with patients with type II disease (grade 3, clear cell and serous histology), type I patients were younger (age 55 versus 59years; p<0.01) and a higher proportion had lower-stage disease (90% versus 71%; p<0.01). US-born Asians also had a significantly higher proportion of type I uterine cancers than immigrant Asians (65% versus 56%;p<0.01). Among immigrant Asians, the proportion with type I cancers was lowest in Japanese followed by Chinese and Filipino women (48% versus 52% versus 58%; p<0.01). The 5-year disease-specific survivals of US-born Asians versus immigrant Asians with type I cancer was 92% for both groups. Over three time periods (2001-2003, 2004-2006, and 2007-2009), there was an increase in type I uterine cancers among US-born Asians (61% to 65% to 68%; p<0.01). Interpretation: US-born Asians are more likely to be diagnosed with type I uterine cancer than immigrant Asians. [ABSTRACT FROM AUTHOR]