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Your search keyword '"Suyalatu, Suyalatu"' showing total 4 results
Start Over Author "Suyalatu, Suyalatu" Topic asian people
4 results on '"Suyalatu, Suyalatu"'

1. Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia.

Author

Bai H, Guo X, Narisu N, Lan T, Wu Q, Xing Y, Zhang Y, Bond SR, Pei Z, Zhang Y, Zhang D, Jirimutu J, Zhang D, Yang X, Morigenbatu M, Zhang L, Ding B, Guan B, Cao J, Lu H, Liu Y, Li W, Dang N, Jiang M, Wang S, Xu H, Wang D, Liu C, Luo X, Gao Y, Li X, Wu Z, Yang L, Meng F, Ning X, Hashenqimuge H, Wu K, Wang B, Suyalatu S, Liu Y, Ye C, Wu H, Leppälä K, Li L, Fang L, Chen Y, Xu W, Li T, Liu X, Xu X, Gignoux CR, Yang H, Brody LC, Wang J, Kristiansen K, Burenbatu B, Zhou H, and Yin Y

Subjects
Americas epidemiology, Asia, Northern epidemiology, Asian People statistics & numerical data, Europe epidemiology, Asia, Eastern epidemiology, Female, Gene Flow, Genome, Human, Humans, Male, Mongolia ethnology, Phylogeny, Whole Genome Sequencing, Asian People ethnology, Asian People genetics, Genetics, Population
Abstract

The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.

Published
2018
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2. The genome of a Mongolian individual reveals the genetic imprints of Mongolians on modern human populations.

Author

Bai H, Guo X, Zhang D, Narisu N, Bu J, Jirimutu J, Liang F, Zhao X, Xing Y, Wang D, Li T, Zhang Y, Guan B, Yang X, Yang Z, Shuangshan S, Su Z, Wu H, Li W, Chen M, Zhu S, Bayinnamula B, Chang Y, Gao Y, Lan T, Suyalatu S, Huang H, Su Y, Chen Y, Li W, Yang X, Feng Q, Wang J, Yang H, Wang J, Wu Q, Yin Y, and Zhou H

Subjects
Carnitine deficiency, Carnitine genetics, Gene Deletion, Humans, Male, Mongolia, Mutagenesis, Insertional, Polymorphism, Single Nucleotide, Asian People genetics, Evolution, Molecular, Gene Flow, Genome, Human, Population genetics
Abstract

Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]-1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on other human populations have been lacking. We here present the genome of a Mongolian male individual. The genome was de novo assembled using a total of 130.8-fold genomic data produced from massively parallel whole-genome sequencing. We identified high-confidence variation sets, including 3.7 million single nucleotide polymorphisms (SNPs) and 756,234 short insertions and deletions. Functional SNP analysis predicted that the individual has a pathogenic risk for carnitine deficiency. We located the patrilineal inheritance of the Mongolian genome to the lineage D3a through Y haplogroup analysis and inferred that the individual has a common patrilineal ancestor with Tibeto-Burman populations and is likely to be the progeny of the earliest settlers in East Asia. We finally investigated the genetic imprints of Mongolians on other human populations using different approaches. We found varying degrees of gene flows between Mongolians and populations living in Europe, South/Central Asia, and the Indian subcontinent. The analyses demonstrate that the genetic impacts of Mongolians likely resulted from the expansion of the Mongolian Empire in the 13th century. The genome will be of great help in further explorations of modern human evolution and genetic causes of diseases/traits specific to Mongolians., (© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)

Published
2014
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3. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China

Author

Xiuqin Yang, Narisu Narisu, Shandan Chu, Burenbatu Borjigin, Tianming Lan, Haihua Bai, Olga L. Posukh, Qizhu Wu, Guilan Guilan, Suyalatu Suyalatu, Ying Chen, Yuriy L. Orlov, Haiping Liu, Xiaosen Guo, and Ludmila P. Osipova

Subjects
Adult, Genetic Markers, Male, Quality Control, China, endocrine system, Genotype, Article Subject, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Population, Genome-wide association study, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Body Mass Index, Endocrinology, Asian People, Gene Frequency, Humans, Genetic Predisposition to Disease, Allele, education, Allele frequency, Alleles, Triglycerides, Aged, Genetic association, Genetics, education.field_of_study, lcsh:RC648-665, Genetic heterogeneity, Genetic Variation, nutritional and metabolic diseases, Mongolia, Middle Aged, Fixation (population genetics), Logistic Models, Diabetes Mellitus, Type 2, Female, Genome-Wide Association Study, Research Article
Abstract

The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.

Published
2015
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4. The genome of a Mongolian individual reveals the genetic imprints of Mongolians on modern human populations

Author

Jian Wang, Xukui Yang, Baozhu Guan, Xiang Zhao, Tongda Li, Qizhu Wu, Suyalatu Suyalatu, Shilin Zhu, Wenjing Li, Tianming Lan, Wenqi Li, Ye Yin, Yanru Zhang, Dingzhu Wang, Jun Wang, Fan Liang, Shuangshan Shuangshan, Ming Chen, Yujie Chen, Haihua Bai, Jirimutu Jirimutu, Zhe Su, Hui Huang, Yanping Xing, Yan Su, Qiang Feng, Dong Zhang, Xiaosen Guo, Junjie Bu, Xu Yang, Huanmin Zhou, Bayinnamula Bayinnamula, Ying Gao, Narisu Narisu, Huiguang Wu, Zili Yang, Huanming Yang, and Yuqi Chang

Subjects
Gene Flow, Male, Lineage (genetic), Human Y-chromosome DNA haplogroup, Population, Single-nucleotide polymorphism, Biology, de novo assembly, Genome, Polymorphism, Single Nucleotide, Evolution, Molecular, Asian People, Carnitine, Genetic variation, Genetics, otorhinolaryngologic diseases, Humans, Mongolian genome, education, Ecology, Evolution, Behavior and Systematics, Research Articles, patrilineal origin, education.field_of_study, Genome, Human, Mongolia, Mutagenesis, Insertional, Human evolution, genetic imprints, sense organs, genetic variations, Gene Deletion, SNP array
Abstract

Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]-1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on other human populations have been lacking. We here present the genome of a Mongolian male individual. The genome was de novo assembled using a total of 130.8-fold genomic data produced from massively parallel whole-genome sequencing. We identified high-confidence variation sets, including 3.7 million single nucleotide polymorphisms (SNPs) and 756,234 short insertions and deletions. Functional SNP analysis predicted that the individual has a pathogenic risk for carnitine deficiency. We located the patrilineal inheritance of the Mongolian genome to the lineage D3a through Y haplogroup analysis and inferred that the individual has a common patrilineal ancestor with Tibeto-Burman populations and is likely to be the progeny of the earliest settlers in East Asia. We finally investigated the genetic imprints of Mongolians on other human populations using different approaches. We found varying degrees of gene flows between Mongolians and populations living in Europe, South/Central Asia, and the Indian subcontinent. The analyses demonstrate that the genetic impacts of Mongolians likely resulted from the expansion of the Mongolian Empire in the 13th century. The genome will be of great help in further explorations of modern human evolution and genetic causes of diseases/traits specific to Mongolians.

Published
2014

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