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Effect of ascorbic acid on hemato-biochemical and hormonal profile of swamp buffaloes were investigated during summer and post summer months. Eighteen swamp buffaloes (Avg. b.wt.336.24±10.27kg, age 3.5 years) were divided randomly into three groups of six each. The animals were supplemented with ascorbic acid (AA) at the rate of 0, 10 and 15 g/animal/day for 150 days and designated as T1 T2 and T3. Blood was collected on 0, 30th, 60th, 90th, 120th and 150th day of the experiment and analysed. Results indicated that the value of haemoglobin (Hb), Packed Cell Volume (PCV) and thyroxin was higher (p 0.05) higher while total leucocytic count (TLC), neutrophil, eosinophil, total protein, AST (Aspertate aminotransferase) and ALT (Alanine aminotransferase) was lower in T2 and T3 as compared to T1. Across the treatment T2 and T3 showed significantly (p

The floral richness of the North-East Indian region cannot be neglected in context to its medicinal importance. Achyranthes aspera Linn. (Amaranthaceae; Prickly Chaff flower) is an indigenous plant species of this region. Although the local traditional healers have ethnomedical knowledge on the use of this plant, there is no scientific study on wound-healing activity of this plant.The healing efficacy of methanol leaf extract of A. aspera (MEAA) in granulation tissue of burn wound and its antioxidant activity are investigated.Methanol extract of leaves of A. aspera was used for compounding 5% (w/w) ointment, which was applied topically twice daily in experimental burn wound in rats. Healing potential was assessed by rate of wound contraction, antioxidant and biochemical assay which was supported by gelatin zymography and histopathology.In the present study, 5% ointment of A. aspera showed significant (p0.05) wound healing, which was evident by wound contraction, elevation of various antioxidant enzymes viz. SOD, catalase, vitamin C and prohealing and biochemical parameters like hydroxyproline and protein content than the control animals. Up-regulated expression of matrix metalloproteinases (MMP-2 and 9) was also observed by gelatin zymography. Histopathological examination of the granulation tissues in the A. aspera-treated animals showed collagen deposition, fibroblast proliferation and formation of epidermis.The methanol leaf extract of A. aspera showed excellent wound-healing activities which has great potential for development of plant-based product.