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Binuclear copper complex (2-[bis(2-aminoethyl)amino]ethanol, 4,4′-bipyridine bridged dicopper(II) complex) was grafted onto the surface of a glassy carbon electrode (GCE) using the cyclic voltammetric method in a phosphate buffer solution (PBS). The modified electrode resulted in efficient electrocatalytic activity for anodic oxidation of uric acid (UA) and ascorbic acid (AA) via a substantial decrease in anodic over-potentials for both compounds. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using this modified electrode result in two well-resolved anodic waves for the oxidation of UA and AA in mixed solution, making possible the simultaneous determination of both compounds. Linear analytical curves were obtained in the ranges 5.0–300.0 μM and 5.0–160.0 μM for UA and AA concentrations through DPV methods, respectively. The detection limits were 2.0 μM of UA and AA. This electrode was used for UA and AA determinations in urine samples with satisfactory results. [ABSTRACT FROM AUTHOR]

A novel modified glassy carbon electrode (GCE) with a binuclear copper complex was fabricated using a cyclic voltammetric method in phosphate buffer solution. This modified electrode shows very efficient electrocatalytic activity for anodic oxidation of both dopamine (DA) and ascorbic acid (AA) via substantial decrease in anodic overpotentials for both compounds. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using this modified electrode show two well-resolved anodic waves for the oxidation of DA and AA in mixed solution, which makes it possible for simultaneous determination of both compounds. Linear analytical curves were obtained in the ranges 2.0–120.0 μM and 5.0–160.0 μM for DA and AA concentrations by using DPV methods, respectively. The detection limits were 1.4 × 10−6 M of DA and 2.8 × 10−6 M of AA. This electrode was used for AA and DA determinations in medicine and foodstuff samples with satisfactory results. [ABSTRACT FROM AUTHOR]