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Diagnosing oral diseases at an early stage may lead to better preventive treatments, thus reducing treatment burden and costs. This paper introduces a systematic design of a microfluidic compact disc (CD) consisting of six unique chambers that run simultaneously from sample loading, holding, mixing and analysis. In this study, the electrochemical property changes between real saliva and artificial saliva mixed with three different types of mouthwashes (i.e. chlorhexidine-, fluoride- and essential oil (Listerine)-based mouthwashes) were investigated using electrical impedance analysis. Given the diversity and complexity of patient's salivary samples, we investigated the electrochemical impedance property of healthy real saliva mixed with different types of mouthwashes to understand the different electrochemical property which could be a foundation for diagnosis and monitoring of oral diseases. On the other hand, electrochemical impedance property of artificial saliva, a commonly used moisturizing agent and lubricant for the treatment of xerostomia or dry mouth syndrome was also studied. The findings indicate that artificial saliva and fluoride-based mouthwash showed higher conductance values compared to real saliva and two other different types of mouthwashes. The ability of our new microfluidic CD platform to perform multiplex processes and detection of electrochemical property of different types of saliva and mouthwashes is a fundamental concept for future research on salivary theranostics using point-of-care microfluidic CD platform. [ABSTRACT FROM AUTHOR]

Nitinol (NiTi) alloy is a widely used material for the production of orthodontic archwires. Its corrosion behavior in conditions that exist in the oral cavity still remains a great characterization challenge. The motivation behind this work is to reveal the influence of commercially available mouthwashes on NiTi orthodontic archwires by performing non-electrochemical corrosion tests and quantifying the changes in the nanotopography of commercially available NiTi orthodontic wires. In this study, we examined the behavior of NiTi alloy archwires exposed for 21.5 days to different corrosive media: artificial saliva, Eludril®, Aquafresh®, and Listerine®. The corrosion was characterized by contact mode atomic force microscopy (AFM) before and after the corrosion tests. A novel analysis methodology was developed to obtain insight into locations of material gain or material loss based on standard surface roughness parameters Sa, Sdr, Ssk, and S10z. The developed methodology revealed that fluoride-containing mouthwashes (Aquafresh® and Listerine®) dominantly cause material loss, while chloride-containing mouthwash (Eludril®) can cause both material loss and material gain. The sample exposed to artificial saliva did not display significant changes in any parameter. [ABSTRACT FROM AUTHOR]

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The aim of this study was to tackle the topic of appropriate recommendations for artificial-saliva and mouthwash usage. The contact angle, pH, and conductivity of two artificial saliva solutions, four mouthwashes, and their mixtures on enamel, glass-ionomer, and composite dental materials were measured. The measurements were conducted with a MATLAB algorithm to minimize human error. The obtained values for the contact angle were in the range from 7.98° to 52.6°, and they showed completely nonlinear and nonuniform behavior for all investigated liquids and on all investigated substrates. Results reveal statistically significant differences among all tested liquids on all investigated substrates (p < 0.05). pH values ranged from 1.54 to 7.01. A wide range of conductivity values were observed, from 1205µS/cm in the saliva-stimulating solution to 6679 mS/cm in the artificial saliva. Spearman's test showed a moderate positive correlation between the pH and conductivity of the tested fluids (R = 0.7108). A comparison of the data obtained using Image J software and the MATLAB algorithm showed consistency, not exceeding 5% error. When an experiment uses human material and bioactive materials THAT are used in biomedicine as substrates, an additional definition of protocols is highly recommended for future research on this topic. [ABSTRACT FROM AUTHOR]

In this paper, we propose a microfluidic approach for measuring pH, dissolved oxygen (O2), and carbon dioxide (CO2) in human saliva. The proposed innovative method combines the advantages of a microfluidic approach, i.e., small amounts of samples and reagents and precise control of the experimental conditions, with rapid measurements of significant parameters of saliva. The novel design of a microfluidic chip with integrated commercially available PreSens sensors was used for examining the effect of Chlorhexidine on artificial saliva (AS), stimulated saliva (SS), and non-stimulated saliva (NSS). The measurement results showed that for persons with an initially low saliva pH, the use of Chlorhexidine increased the pH, and afterward, the pH value returned to the initial value or higher. However, measurements of volunteers with initial pH close to neutral showed that Chlorhexidine reduced the pH value, increasing the risk of erosion and demineralization. In conclusion, the proposed methodology showed potential for precise measurements of pH in saliva samples; however, further research is required to examine the influence of the sample collection method on the amounts of O2 and CO2 in saliva. [ABSTRACT FROM AUTHOR]