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Tachycardia is defined as a heart rate greater than 100 bpm for more than 1 min. Tachycardia often occurs after endotracheal intubation and can cause serious complication in patients with cardiovascular disease. The ability to predict post-intubation tachycardia would help clinicians by notifying a potential event to pre-treat. In this paper, we predict the potential post-intubation tachycardia. Given electronic medical record and vital signs collected before tracheal intubation, we predict whether post-intubation tachycardia will occur within 10 min. Of 1931 available patient datasets, 257 remained after filtering those with inappropriate data such as outliers and inappropriate annotations. Three feature sets were designed using feature selection algorithms, and two additional feature sets were defined by statistical inspection or manual examination. The five feature sets were compared with various machine learning models such as naïve Bayes classifiers, logistic regression, random forest, support vector machines, extreme gradient boosting, and artificial neural networks. Parameters of the models were optimized for each feature set. By 10-fold cross validation, we found that an logistic regression model with eight-dimensional hand-crafted features achieved an accuracy of 80.5%, recall of 85.1%, precision of 79.9%, an F1 score of 79.9%, and an area under the receiver operating characteristic curve of 0.85. [ABSTRACT FROM AUTHOR]

While the exchange of data files or programs on the Internet grows exponentially, most users are vulnerable to infected files, especially to malicious non-executables. Due to the circumstances between South and North Korea, many malicious actions have recently been found in Hangul Word Processor (HWP) non-executable files because the HWP is widely used in schools, military facilities, and government institutions of South Korea. The HWP file usually has one or more byte streams that are often used for the malicious actions. Based on an assumption that infected byte streams have particular patterns, we design a convolutional neural network (CNN) to grasp such patterns. We conduct experiments on our prepared 534 HWP files, and demonstrate that the proposed CNN achieves the best performance compared to other machine learning models. As new malicious attacks keep emerging, we will keep collecting such HWP files and investigate better model structures. [ABSTRACT FROM AUTHOR]

With increasing amount of data, the threat of malware keeps growing recently. The malicious actions embedded in nonexecutable documents especially (e.g., PDF files) can be more dangerous, because it is difficult to detect and most users are not aware of such type of malicious attacks. In this paper, we design a convolutional neural network to tackle the malware detection on the PDF files. We collect malicious and benign PDF files and manually label the byte sequences within the files. We intensively examine the structure of the input data and illustrate how we design the proposed network based on the characteristics of data. The proposed network is designed to interpret high-level patterns among collectable spatial clues, thereby predicting whether the given byte sequence has malicious actions or not. By experimental results, we demonstrate that the proposed network outperform several representative machine-learning models as well as other networks with different settings. [ABSTRACT FROM AUTHOR]

Hypotensive events in the initial stage of anesthesia can cause serious complications in the patients after surgery, which could be fatal. In this study, we intended to predict hypotension after tracheal intubation using machine learning and deep learning techniques after intubation one minute in advance. Meta learning models, such as random forest, extreme gradient boosting (Xgboost), and deep learning models, especially the convolutional neural network (CNN) model and the deep neural network (DNN), were trained to predict hypotension occurring between tracheal intubation and incision, using data from four minutes to one minute before tracheal intubation. Vital records and electronic health records (EHR) for 282 of 319 patients who underwent laparoscopic cholecystectomy from October 2018 to July 2019 were collected. Among the 282 patients, 151 developed post-induction hypotension. Our experiments had two scenarios: using raw vital records and feature engineering on vital records. The experiments on raw data showed that CNN had the best accuracy of 72.63%, followed by random forest (70.32%) and Xgboost (64.6%). The experiments on feature engineering showed that random forest combined with feature selection had the best accuracy of 74.89%, while CNN had a lower accuracy of 68.95% than that of the experiment on raw data. Our study is an extension of previous studies to detect hypotension before intubation with a one-minute advance. To improve accuracy, we built a model using state-of-art algorithms. We found that CNN had a good performance, but that random forest had a better performance when combined with feature selection. In addition, we found that the examination period (data period) is also important. [ABSTRACT FROM AUTHOR]