1. Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation
- Author
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Domenico Camboni, Davide Ferraro, Thomas Schlöglhofer, Fabio Bernini, Guido Giudetti, Calogero Maria Oddo, Giacomo D'Alesio, Jacopo Carpaneto, Valentina Casieri, Vincenzo Lionetti, Domiziana Terlizzi, Leone Costi, Philipp Aigner, Martin Maw, Francesco Moscato, Max Haberbusch, Andrea Aliperta, Silvestro Micera, Ewald Unger, Luca Massari, Gianni Pedrizzetti, Ciro Zinno, Ferraro, D., D'Alesio, G., Camboni, D., Zinno, C., Costi, L., Haberbusch, M., Aigner, P., Maw, M., Schloglhofer, T., Unger, E., Aliperta, A., Bernini, F., Casieri, V., Terlizzi, D., Giudetti, G., Carpaneto, J., Pedrizzetti, G., Micera, S., Lionetti, V., Moscato, F., Massari, L., and Oddo, C. M.
- Subjects
fiber bragg grating ,Cardiac function curve ,Computer science ,fiber gratings ,heart ,sensors ,doppler ,pressure ,symbols.namesake ,strain ,Fiber Bragg grating ,increase ,Heart rate ,medicine ,heart monitoring ,neural networks ,Electrical and Electronic Engineering ,Instrumentation ,Artificial neural network ,optical fiber sensors ,medicine.disease ,Soft sensor ,monitoring ,Recurrent neural network ,Heart failure ,cardiovascular system ,symbols ,rate-variability ,Doppler effect ,mechanical sensors ,Biomedical engineering - Abstract
Continuous and reliable cardiac function monitoring could improve medication adherence in patients at risk of heart failure. This work presents an innovative implantable Fiber Bragg Grating-based soft sensor designed to sense mechanical cardiac activity. The sensor was tested in an isolated beating ovine heart platform, with 3 different hearts operated in wide-ranging conditions. In order to investigate the sensor capability to track the ventricular beats in real-time, two causal algorithms were proposed for detecting the beats from sensor data and to discriminate artifacts. The first based on dynamic thresholds while the second is a hybrid convolutional and recurrent Neural Network. An error of 2.7 +/- 0.7 beats per minute was achieved in tracking the heart rate. Finally, we have confirmed the sensor reliability in monitoring the heart activity of healthy adult minipig with an error systematically lower than 1 Bpm.
- Published
- 2021