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COVID-19 is an infectious disease that mostly affects the respiratory system. At the time of this research being performed, there were more than 1.4 million cases of COVID-19, and one of the biggest anxieties is not just our health, but our livelihoods, too. In this research, authors investigate the impact of COVID-19 on the global economy, more specifically, the impact of COVID-19 on financial movement of Crude Oil price and three U.S. stock indexes: DJI, S&P 500 and NASDAQ Composite. The proposed system for predicting commodity and stock prices integrates the Stationary Wavelet Transform (SWT) and Bidirectional Long Short-Term Memory (BDLSTM) networks. Firstly, SWT is used to decompose the data into approximation and detail coefficients. After decomposition, data of Crude Oil price and stock market indexes along with COVID-19 confirmed cases were used as input variables for future price movement forecasting. As a result, the proposed system BDLSTM+WT-ADA achieved satisfactory results in terms of five-day Crude Oil price forecast., 26 pages, 9 figures

Authors present a Multilayer Perceptron (MLP) artificial neural network (ANN) method for the purpose of estimating a speed of a frigate using a combined diesel-electric and gas (CODLAG) propulsion system. Dataset used is publicly available, as condition-based maintenance of naval propulsion plants dataset, out of which GT Compressor decay state coefficient and GT Turbine decay state coefficient are unused, while 15 features are used as input and ship speed is used as dataset output. Data set consists of 11934 data points out of which 8950 (75%) are used as a training set and 2984 (25%) are used as a testing set. 26880 MLPs, with 8960 different parameter combinations are trained using a grid search algorithm, quality of each solution being estimated with coefficient of determination (R2) and mean absolute error (MAE). Results show that a high-quality estimation can be made using an MLP, with best result having an error of just 3.4485x10-5 knots (absolute error of 0.00014% of the range). This result was achieved with a MLP with three hidden layers containing 100 neurons each, logistic activation function, LBFGS solver, constant learning rate of 0.1 and no L2 regularization.

Inverse kinematic equations allow the determination of the joint angles necessary for the robotic manipulator to place a tool into a predefined position. Determining this equation is vital but a complex work. In this article, an artificial neural network, more specifically, a feed-forward type, multilayer perceptron (MLP), is trained, so that it could be used to calculate the inverse kinematics for a robotic manipulator. First, direct kinematics of a robotic manipulator are determined using Denavit–Hartenberg method and a dataset of 15,000 points is generated using the calculated homogenous transformation matrices. Following that, multiple MLPs are trained with 10,240 different hyperparameter combinations to find the best. Each trained MLP is evaluated using the R 2 and mean absolute error metrics and the architectures of the MLPs that achieved the best results are presented. Results show a successful regression for the first five joints (percentage error being less than 0.1%) but a comparatively poor regression for the final joint due to the configuration of the robotic manipulator.

One of the challenges of maritime affairs is automatic object recognition from aerial imagery. This can be achieved by utilizing a Convolutional Neural Network (CNN) based algorithm. For purposes of this research, a dataset of 5608 marine object images is collected by using Google satellite imagery and Google Image Search. The dataset is divided into two main classes (“Vessels” and “Other objects”) and each class is divided into four sub-classes (“Vessels” sub- classes are “Cargo ships”, “Cruise ships”, “War ships” and “Boats”, while “Other objects” sub- classes are “Waves”, “Marine animals”, “Garbage patches” and “Oil spills”). For recognition of marine objects, an algorithm constructed with three CNNs is proposed. The first CNN for classification on the main classes achieves accuracy of 92.37 %. The CNN used for vessels recognition achieves accuracies of 94.12 % for cargo ships recognition, 98.82 % for cruise ships recognition, 97.64 % for warships recognition and 95.29 % for boat recognition. The CNN used for recognition of other objects achieves accuracies of 88.56 % for waves and marine animals recognition, 96.92 % for garbage patches recognition and 89.21 % for oil spills recognition. This research has shown that CNN is appropriate artificial intelligence (AI) method for marine object recognition from aerial imagery.

Since the outbreak of coronavirus disease-2019 (COVID-19), the whole world has taken interest in the mechanisms of its spread and development. Mathematical models have been valuable instruments for the study of the spread and control of infectious diseases. For that purpose, we propose a two-way approach in modeling COVID-19 spread: a susceptible, exposed, infected, recovered, deceased (SEIRD) model based on differential equations and a long short-term memory (LSTM) deep learning model. The SEIRD model is a compartmental epidemiological model with included components: susceptible, exposed, infected, recovered, deceased. In the case of the SEIRD model, official statistical data available online for countries of Belgium, Netherlands, and Luxembourg (Benelux) in the period of March 15 2020 to March 15 2021 were used. Based on them, we have calculated key parameters and forward them to the epidemiological model, which will predict the number of infected, deceased, and recovered people. Results show that the SEIRD model is able to accurately predict several peaks for all the three countries of interest, with very small root mean square error (RMSE), except for the mild cases (maximum RMSE was 240.79 ± 90.556), which can be explained by the fact that no official data were available for mild cases, but this number was derived from other statistics. On the other hand, LSTM represents a special kind of recurrent neural network structure that can comparatively learn long-term temporal dependencies. Results show that LSTM is capable of predicting several peaks based on the position of previous peaks with low values of RMSE. Higher values of RMSE are observed in the number of infected cases in Belgium (RMSE was 535.93) and Netherlands (RMSE was 434.28), and are expected because of thousands of people getting infected per day in those countries. In future studies, we will extend the models to include mobility information, variants of concern, as well as a medical intervention, etc. A prognostic model could help us predict epidemic peaks. In that way, we could react in a timely manner by introducing new or tightening existing measures before the health system is overloaded.

Estimation of the epidemiology curve for the COVID-19 pandemic can be a very computationally challenging task. Thus far, there have been some implementations of artificial intelligence (AI) methods applied to develop epidemiology curve for a specific country. However, most applied AI methods generated models that are almost impossible to translate into a mathematical equation. In this paper, the AI method called genetic programming (GP) algorithm is utilized to develop a symbolic expression (mathematical equation) which can be used for the estimation of the epidemiology curve for the entire U.S. with high accuracy. The GP algorithm is utilized on the publicly available dataset that contains the number of confirmed, deceased and recovered patients for each U.S. state to obtain the symbolic expression for the estimation of the number of the aforementioned patient groups. The dataset consists of the latitude and longitude of the central location for each state and the number of patients in each of the goal groups for each day in the period of 22 January 2020&ndash, 3 December 2020. The obtained symbolic expressions for each state are summed up to obtain symbolic expressions for estimation of each of the patient groups (confirmed, deceased and recovered). These symbolic expressions are combined to obtain the symbolic expression for the estimation of the epidemiology curve for the entire U.S. The obtained symbolic expressions for the estimation of the number of confirmed, deceased and recovered patients for each state achieved R2 score in the ranges 0.9406&ndash, 0.9992, 0.9404&ndash, 0.9998 and 0.9797&ndash, 0.99955, respectively. These equations are summed up to formulate symbolic expressions for the estimation of the number of confirmed, deceased and recovered patients for the entire U.S. with achieved R2 score of 0.9992, 0.9997 and 0.9996, respectively. Using these symbolic expressions, the equation for the estimation of the epidemiology curve for the entire U.S. is formulated which achieved R2 score of 0.9933. Investigation showed that GP algorithm can produce symbolic expressions for the estimation of the number of confirmed, recovered and deceased patients as well as the epidemiology curve not only for the states but for the entire U.S. with very high accuracy.

INTRODUCTION: As a result of this global health crisis caused by the COVID-19 pandemic, the medical industry is searching for innovations that have the potential to automate the diagnostic process of COVID-19 and serve as an assistive tool for clinicians. OBJECTIVES: X-ray images have shown to be useful in the diagnosis of COVID-19. The goal of this research is to demonstrate an approach for automatic segmentation of lungs in chest X-ray images. METHODS: In this research DeepLabv3+ with Xception_65, MobileNetV2, and ResNet101 as backbones are used in order to perform lung segmentation. RESULTS: The proposed approach was experimented on X-ray images and has achieved an average mIOU of 0.910, F1 of 0.925, accuracy of 0.968, precision of 0.916, sensitivity of 0.935, and specificity of 0.977. CONCLUSION: Based on the obtained results, the proposed approach proved to be successful in terms of lung segmentation in chest X-ray images and has a great potential for clinical use.

The importance of error detection is high, especially in modern manufacturing processes where assembly lines operate without direct supervision. Stopping the faulty operation in time can prevent damage to the assembly line. Public dataset is used, containing 15 classes, 2 types of faultless operation and 13 types of faults, with 463 force and torsion datapoints. Four different methods are used: Multilayer Perceptron (MLP) selected due to high classification performance, Support Vector Machines (SVM) commonly used for a low number of datapoints, Convolutional Neural Network (CNN) known for high performance in classification with matrix inputs and Siamese Neural Network (SNN) novel method with high performance in small datasets. Two classification tasks are performed-error detection and classification. Grid search is used for hyperparameter variation and F1 score as a metric, with a 10 fold cross-validation. Authors propose a hybrid system consisting of SNN for detection and CNN for fault classification.

Background and objectives Although ML has been studied for different epidemiological and clinical issues as well as for survival prediction of COVID-19, there is a noticeable shortage of literature dealing with ML usage in prediction of disease severity changes through the course of the disease. In that way, predicting disease progression from mild towards moderate, severe and critical condition, would help not only to respond in a timely manner to prevent lethal results, but also to minimize the number of patients in hospitals where this is not necessary. Methods We present a methodology for the classification of patients into 4 distinct categories of the clinical condition of COVID-19 disease. Classification of patients is based on the values of blood biomarkers that were assessed by Gradient boosting regressor and which were selected as biomarkers that have the greatest influence in the classification of patients with COVID-19. Results The results show that among several tested algorithms, XGBoost classifier achieved best results with an average accuracy of 94% and an average F1-score of 94.3%. We have also extracted 10 best features from blood analysis that are strongly associated with patient condition and based on those features we can predict the severity of the clinical condition. Conclusions The main advantage of our system is that it is a decision tree-based algorithm which is easier to interpret, instead of the use of black box models, which are not appealing in medical practice., Graphical abstract Image 1

INTRODUCTION: The development of epidemiological curve models is one of the key factors in the combat of epidemiological diseases such as COVID-19. OBJECTIVES: The goal of this paper is to develop a system for automatic training and testing of AI-based regressive models of epidemiological curves using public data, which involves automating the data acquisition and speeding up the training of the models. METHODS: The research applies Multilayer Perceptron (MLP) for the creation of models, implemented within a system for automatic data fetching and training, and evaluated using the coefficient of determination (R2). Training time is lowered through the application of data filtering and simplifying the model selection. RESULTS: The developed system can train high precision models rapidly, allowing for quick model delivery All trained models achieve scores which are higher than 0.95. CONCLUSION: The results show that the development of a quick COVID-19 spread modeling system is possible.

Nowadays, with the rise of drone and satellite technology, there is a possibility for its application in sea and coastal surveillance. An advantage of this type of application is the automated recognition of marine objects, among which the most important are vessels. This paper presents the principle of vessel recognition based on the extraction of satellite image features of the vessel and the application of a multilayer perceptron (MLP). Dataset used in this research contains the total of 2750 images, where 2112 images are used as training set while the remaining 638 images are used for testing purposes. The SIFT and SURF algorithms were used to extract image features, which were later used as the input vector for MLP.The best results are achieved if a model with four hidden layers is used. These layers are constructed with 32, 128, 32, 128 neurons with ReLU activation function, respectively. Regarding the application of feature extraction, it can be observed that better results are achieved if the SIFT algorithm is used. The ROC AUC value achieved with the combination of SIFT and MLP reaches 0.99.

Urinary bladder cancer is one of the most common cancers of the urinary tract. This cancer is characterized by its high metastatic potential and recurrence rate. Due to the high metastatic potential and recurrence rate, correct and timely diagnosis is crucial for successful treatment and care. With the aim of increasing diagnosis accuracy, artificial intelligence algorithms are introduced to clinical decision making and diagnostics. One of the standard procedures for bladder cancer diagnosis is computer tomography (CT) scanning. In this research, a transfer learning approach to the semantic segmentation of urinary bladder cancer masses from CT images is presented. The initial data set is divided into three sub-sets according to image planes: frontal (4413 images), axial (4993 images), and sagittal (996 images). First, AlexNet is utilized for the design of a plane recognition system, and it achieved high classification and generalization performances with an AUCmicro¯ of 0.9999 and σ(AUCmicro) of 0.0006. Furthermore, by applying the transfer learning approach, significant improvements in both semantic segmentation and generalization performances were achieved. For the case of the frontal plane, the highest performances were achieved if pre-trained ResNet101 architecture was used as a backbone for U-net with DSC¯ up to 0.9587 and σ(DSC) of 0.0059. When U-net was used for the semantic segmentation of urinary bladder cancer masses from images in the axial plane, the best results were achieved if pre-trained ResNet50 was used as a backbone, with a DSC¯ up to 0.9372 and σ(DSC) of 0.0147. Finally, in the case of images in the sagittal plane, the highest results were achieved with VGG-16 as a backbone. In this case, DSC¯ values up to 0.9660 with a σ(DSC) of 0.0486 were achieved. From the listed results, the proposed semantic segmentation system worked with high performance both from the semantic segmentation and generalization standpoints. The presented results indicate that there is the possibility for the utilization of the semantic segmentation system in clinical practice.

In this chapter, a methodology for the utilization of edge-detector based hybrid artificial neural network (ANN) models for urinary bladder cancer is presented. The diagnosis of the bladder cancer can often be complex and it requires invasive diagnostic methods such as biopsy and histopatological evaluation. ANN utilization can provide faster and less invasive diagnosis. The methodology of ANN utilization for urinary bladder cancer diagnosis is based on images obtained with confocal laser endomicroscope during cystoscopy. Such approach can be challenging from the standpoint of computational resources, due to ANN model complexity. Higher computational resources are often inaccessible, especially in clinical practice. Here lies a motive for simplification of ANN models for urinary bladder cancer diagnosis. For these reasons, edge detector-based hybrid models are introduced due to their simpler architectures. From obtained results, it can be noticed that the highest performances are achieved with Laplacian-based convolutional neural network (CNN) model. On the other hand, such approach requires more complex CNN architectures in comparison to gradient-based hybrid CNN models. If Sobel edge detector is utilized, similar classification performances are achieved with less complex CNN model.

Coronavirus (COVID-19) is a highly infectious disease that has captured the attention of the worldwide public. Modeling of such diseases can be extremely important in the prediction of their impact. While classic, statistical, modeling can provide satisfactory models, it can also fail to comprehend the intricacies contained within the data. In this paper, authors use a publicly available dataset, containing information on infected, recovered, and deceased patients in 406 locations over 51 days (22nd January 2020 to 12th March 2020). This dataset, intended to be a time-series dataset, is transformed into a regression dataset and used in training a multilayer perceptron (MLP) artificial neural network (ANN). The aim of training is to achieve a worldwide model of the maximal number of patients across all locations in each time unit. Hyperparameters of the MLP are varied using a grid search algorithm, with a total of 5376 hyperparameter combinations. Using those combinations, a total of 48384 ANNs are trained (16128 for each patient group—deceased, recovered, and infected), and each model is evaluated using the coefficient of determination (R2). Cross-validation is performed using K-fold algorithm with 5-folds. Best models achieved consists of 4 hidden layers with 4 neurons in each of those layers, and use a ReLU activation function, with R2 scores of 0.98599 for confirmed, 0.99429 for deceased, and 0.97941 for recovered patient models. When cross-validation is performed, these scores drop to 0.94 for confirmed, 0.781 for recovered, and 0.986 for deceased patient models, showing high robustness of the deceased patient model, good robustness for confirmed, and low robustness for recovered patient model.

In this paper, the urinary bladder cancer diagnostic method which is based on Multi-Layer Perceptron and Laplacian edge detector is presented. The aim of this paper is to investigate the implementation possibility of a simpler method (Multi-Layer Perceptron) alongside commonly used methods, such as Deep Learning Convolutional Neural Networks, for the urinary bladder cancer detection. The dataset used for this research consisted of 1997 images of bladder cancer and 986 images of non-cancer tissue. The results of the conducted research showed that using Multi-Layer Perceptron trained and tested with images pre- processed with Laplacian edge detector are achieving AUC value up to 0.99. When different image sizes are compared it can be seen that the best results are achieved if 50*50 and 100*100 images were used.

Authors present a Multilayer Perceptron (MLP) artifi cial neural network (ANN) method for the purpose of estimating a speed of a frigate using a combined diesel-electric and gas (CODLAG) propulsion system. Dataset used is publicly available, as conditionbased maintenance of naval propulsion plants dataset, out of which GT Compressor decay state coeffi cient and GT Turbine decay state coeffi cient are unused, while 15 features are used as input and ship speed is used as dataset output. Data set consists of 11934 data points out of which 8950 (75%) are used as a training set and 2984 (25%) are used as a testing set. 26880 MLPs, with 8960 diff erent parameter combinations are trained using a grid search algorithm, quality of each solution being estimated with coeffi cient of determination (R2) and mean absolute error (MAE). Results show that a high-quality estimation can be made using an MLP, with best result having an error of just 3.4485x10-5 knots (absolute error of 0.00014% of the range). This result was achieved with a MLP with three hidden layers containing 100 neurons each, logistic activation function, LBFGS solver, constant learning rate of 0.1 and no L2 regularization.

Swarm robotics is a field in which multiple robots coordinate their collective behavior autonomously to accomplish a given task without any form of centralized control. In swarm robotics, task allocation refers to the behavior resulting in robots being dynamically distributed over different sub-tasks, which is often required for solving complex tasks. It has been well recognized that evolutionary robotics is a promising approach to the development of collective behaviors for robotic swarms. However, the artificial evolution often suffers from two issues—the bootstrapping problem and deception—especially when the underlying task is profoundly complex. In this study, we propose a two-step scheme consisting of task partitioning and autonomous task allocation to overcome these difficulties. We conduct computer simulation experiments where robotic swarms have to accomplish a complex collective foraging problem, and the results show that the proposed approach leads to perform more effectively than a conventional evolutionary robotics approach.

In this paper multilayer perceptron (MLP) approach to condition-based maintenance of combined diesel-electric and gas (CODLAG) marine propulsion system is presented. By using data available in UCI, online machine learning repository, MLPs for prediction of gas turbine (GT) and GT compressor decay state coefficients are designed. Aforementioned MLPs are trained and tested by using 11 934 samples, of which 9 548 samples are used for training and 2 386 samples are used testing. In the case of GT decay state coefficient prediction, the lowest mean relative error of 0.622 % is achieved if MLP with one hidden layer of 50 artificial neurons (AN) designed with Tanh activation function is utilized. This configuration achieves the best results if it is trained by using L-BFGS solver. In the case of GT compressor decay state coefficient, the best results are achieved if MLP is designed with four hidden layers of 100, 50, 50 and 20 ANs, respectively. This configuration is designed by using Logistic sigmoid activation function. The lowest mean relative error of 1.094 % is achieved if MLP is trained by using L-BFGS solver.

In this study, the use of a popular deep reinforcement learning algorithm – deep Q-learning – in developing end-to-end control policies for robotic swarms is explored. Robots only have limited local sensory capabilities; however, in a swarm, they can accomplish collective tasks beyond the capability of a single robot. Compared with most automatic design approaches proposed so far, which belong to the field of evolutionary robotics, deep reinforcement learning techniques provide two advantages: (i) they enable researchers to develop control policies in an end-to-end fashion; and (ii) they require fewer computation resources, especially when the control policy to be developed has a large parameter space. The proposed approach is evaluated in a round-trip task, where the robots are required to travel between two destinations as much as possible. Simulation results show that the proposed approach can learn control policies directly from high-dimensional raw camera pixel inputs for robotic swarms.

INTRODUCTION: Machine learning algorithms and in silico models for the COVID-19 have been used to classify infectious people and predict their condition in time. OBJECTIVES: This study aims at creating a personalized model that combines machine learning and finite element simulation approach in order to predict development of COVID-19 infection in patients. METHODS: The methodology combines several aspects (1) classification of patients into several classes of clinical condition (2) segmentation of human lungs in X ray images (3) finite element simulation to investigate the spreading of SARS-COV-2 virion in the lungs. RESULTS: The findings show accuracy larger than 90% in all aspects of methodology. FE simulation has revealed that the distribution of airflow in the lung changes in time with the infection. CONCLUSION: The key benefit of our proposed method is that it combines several methods that will be further improved in order to create a truly unique combined methodology for predictive models in patients infected with COVID-19.

Simple Summary One of the main challenges in the application of Machine Learning in medicine is data collection. Either due to ethical concerns or lack of patients, data may be scarce. In this paper Deep Convolutional Generative Adversarial Networks (DCGAN) have been applied for the purpose of data augmentation. Images of bladder mucosa are used in order to generate new images using DCGANs. Then, combination of original and generated images are used to train AlexNet and VGG16 architectures. The results show improvements in AUC score in some cases, or equal scores with apparent lowering of standard deviation across data folds during cross-validation; indicating networks trained with the addition of generated data have a lower sensitivity across the hyperparameter range. Abstract Urinary bladder cancer is one of the most common urinary tract cancers. Standard diagnosis procedure can be invasive and time-consuming. For these reasons, procedure called optical biopsy is introduced. This procedure allows in-vivo evaluation of bladder mucosa without the need for biopsy. Although less invasive and faster, accuracy is often lower. For this reason, machine learning (ML) algorithms are used to increase its accuracy. The issue with ML algorithms is their sensitivity to the amount of input data. In medicine, collection can be time-consuming due to a potentially low number of patients. For these reasons, data augmentation is performed, usually through a series of geometric variations of original images. While such images improve classification performance, the number of new data points and the insight they provide is limited. These issues are a motivation for the application of novel augmentation methods. Authors demonstrate the use of Deep Convolutional Generative Adversarial Networks (DCGAN) for the generation of images. Augmented datasets used for training of commonly used Convolutional Neural Network-based (CNN) architectures (AlexNet and VGG-16) show a significcan performance increase for AlexNet, where AUCmicro reaches values up to 0.99. Average and median results of networks used in grid-search increases. These results point towards the conclusion that GAN-based augmentation has decreased the networks sensitivity to hyperparemeter change.

COVID-19 represents one of the greatest challenges in modern history. Its impact is most noticeable in the health care system, mostly due to the accelerated and increased influx of patients with a more severe clinical picture. These facts are increasing the pressure on health systems. For this reason, the aim is to automate the process of diagnosis and treatment. The research presented in this article conducted an examination of the possibility of classifying the clinical picture of a patient using X-ray images and convolutional neural networks. The research was conducted on the dataset of 185 images that consists of four classes. Due to a lower amount of images, a data augmentation procedure was performed. In order to define the CNN architecture with highest classification performances, multiple CNNs were designed. Results show that the best classification performances can be achieved if ResNet152 is used. This CNN has achieved AUCmacro&macr, and AUCmicro&macr, up to 0.94, suggesting the possibility of applying CNN to the classification of the clinical picture of COVID-19 patients using an X-ray image of the lungs. When higher layers are frozen during the training procedure, higher AUCmacro&macr, values are achieved. If ResNet152 is utilized, AUCmacro&macr, values up to 0.96 are achieved if all layers except the last 12 are frozen during the training procedure.

Lowering joint torques of a robotic manipulator enables lowering the energy it uses as well as increase in the longevity of the robotic manipulator. This article proposes the use of evolutionary computation algorithms for optimizing the paths of the robotic manipulator with the goal of lowering the joint torques. The robotic manipulator used for optimization is modelled after a realistic six-degree-of-freedom robotic manipulator. Two cases are observed and these are a single robotic manipulator carrying a weight in a point-to-point trajectory and two robotic manipulators cooperating and moving the same weight along a calculated point-to-point trajectory. The article describes the process used for determining the kinematic properties using Denavit–Hartenberg method and the dynamic equations of the robotic manipulator using Lagrange–Euler and Newton–Euler algorithms. Then, the description of used artificial intelligence optimization algorithms is given – genetic algorithm using random and average recombination, simulated annealing using linear and geometric cooling strategy and differential evolution. The methods are compared and the results show that the genetic algorithm provides best results in regard to torque minimization, with differential evolution also providing comparatively good results and simulated annealing giving the comparatively weakest results while providing smoother torque curves.

Signals with time-varying frequency content are generally best represented in the time frequency (TF) domain, with the components instantaneous frequency laws being their key nonstationary features. There are a number of methods for TF distribution calculation (TFD), however, most of them add unwanted artifacts, making the TFD interpretation more difficult. In this paper, we use a compressive sensing approach to suppress or completely eliminate those artifacts. Furthermore, a basis pursuit algorithm is employed for signal reconstruction in order to reduce resolution loss, which is a mayor obstacle of existing TFD design methods.

New environmental characteristics and requirements have challenged manufacturing enterprises to improve the efficiency and productivity of their production activities. Cellular manufacturing (CM) as one of the solutions to this problem, as implementation of Group technology (GT), was proposed. Performance of cellular manufacturing systems depends heavily on the cell structure. In this paper we present and evaluate a novel approach for solving the cell-formation problem based on implementation of a GA, called modified genetic algorithm (MGA). Implementation of the GA in here presented simulation model is based on Emergent Synthesis idea, of top-down problem decomposition and emerging solution from bottom-up feedback.