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Objectives: Coronary angiography (CAG)-derived physiology methods have been developed in an attempt to simplify and increase the usage of coronary physiology, based mostly on dynamic fluid computational algorithms. We aimed to develop a different approach based on artificial intelligence methods, which has seldom been explored., Methods: Consecutive patients undergoing invasive instantaneous free-wave ratio (iFR) measurements were included. We developed artificial intelligence (AI) models capable of classifying target lesions as positive (iFR ≤ 0.89) or negative (iFR > 0.89). The predictions were then compared to the true measurements., Results: Two hundred-fifty measurements were included, and 3 models were developed. Model 3 had the best overall performance: accuracy, negative predictive value (NPV), positive predictive value (PPV), sensitivity, and specificity were 69%, 88%, 44%, 74%, and 67%, respectively. Performance differed per target vessel. For the left anterior descending artery (LAD), model 3 had the highest accuracy (66%), while model 2 the highest NPV (86%) and sensitivity (91%). PPV was always low/modest. Model 1 had the highest specificity (68%). For the right coronary artery, model 1's accuracy was 86%, NPV was 97%, and specificity was 87%, but all models had low PPV (maximum 25%) and low/modest sensitivity (maximum 60%). For the circumflex, model 1 performed best: accuracy, NPV, PPV, sensitivity, and specificity were 69%, 96%, 24%, 80%, and 68%, respectively., Conclusions: We developed 3 AI models capable of binary iFR estimation from CAG images. Despite modest accuracy, the consistently high NPV is of potential clinical significance, as it would enable avoiding further invasive maneuvers after CAG. This pivotal study offers proof of concept for further development.

Introduction: Pulmonary embolism (PE) is a life-threatening condition, in which diagnostic uncertainty remains high given the lack of specificity in clinical presentation. It requires confirmation by computed tomography pulmonary angiography (CTPA). Electrocardiography (ECG) signals can be detected by artificial intelligence (AI) with precision. The purpose of this study was to develop an AI model for predicting PE using a 12-lead ECG., Methods: We extracted 1014 ECGs from patients admitted to the emergency department who underwent CTPA due to suspected PE: 911 ECGs were used for development of the AI model and 103 ECGs for validation. An AI algorithm based on an ensemble neural network was developed. The performance of the AI model was compared against the guideline recommended clinical prediction rules for PE (Wells and Geneva scores combined with a standard D-dimer cut-off of 500 ng/mL and an age-adjusted cut-off, PEGeD and YEARS algorithm)., Results: The AI model achieves greater specificity to detect PE than the commonly used clinical prediction rules. The AI model shown a specificity of 100% (95% confidence interval (CI): 94-100) and a sensitivity of 50% (95% CI: 33-67). The AI model performed significantly better than the other models (area under the curve 0.75; 95% CI 0.66-0.82; p<0.001), which had nearly no discriminative power. The incidence of typical PE ECG features was similar in patients with and without PE., Conclusion: We developed and validated a deep learning-based AI model for PE diagnosis using a 12-lead ECG and it demonstrated high specificity., (Copyright © 2023. Publicado por Elsevier España, S.L.U.)

Developments in biotechnology are increasingly dependent on the extensive use of big data, generated by modern high-throughput instrumentation technologies, and stored in thousands of databases, public and private. Future developments in this area depend, critically, on the ability of biotechnology researchers to master the skills required to effectively integrate their own contributions with the large amounts of information available in these databases. This article offers a perspective of the relations that exist between the fields of big data and biotechnology, including the related technologies of artificial intelligence and machine learning and describes how data integration, data exploitation, and process optimization correspond to three essential steps in any future biotechnology project. The article also lists a number of application areas where the ability to use big data will become a key factor, including drug discovery, drug recycling, drug safety, functional and structural genomics, proteomics, pharmacogenetics, and pharmacogenomics, among others., (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Abstract: State merging algorithms have emerged as the solution of choice for the problem of inferring regular grammars from labeled samples, a known NP-complete problem of great importance in the grammatical inference area. These methods derive a small deterministic finite automaton from a set of labeled strings (the training set), by merging parts of the acceptor that corresponds to this training set. Experimental and theoretical evidence have shown that the generalization ability exhibited by the resulting automata is highly correlated with the number of states in the final solution. As originally proposed, state merging algorithms do not perform search. This means that they are fast, but also means that they are limited by the quality of the heuristics they use to select the states to be merged. Sub-optimal choices lead to automata that have many more states than needed and exhibit poor generalization ability. In this work, we survey the existing approaches that generalize state merging algorithms by using search to explore the tree that represents the space of possible sequences of state mergings. By using heuristic guided search in this space, many possible state merging sequences can be considered, leading to smaller automata and improved generalization ability, at the expense of increased computation time. We present comparisons of existing algorithms that show that, in widely accepted benchmarks, the quality of the derived solutions is improved by applying this type of search. However, we also point out that existing algorithms are not powerful enough to solve the more complex instances of the problem, leaving open the possibility that better and more powerful approaches need to be designed. [Copyright &y& Elsevier]