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It is becoming increasingly clear that mitochondria play an important role in neural function. Recent studies show mitochondrial morphology to be crucial to cellular physiology and synaptic function and a link between mitochondrial defects and neuro-degenerative diseases is strongly suspected. Electron microscopy (EM), with its very high resolution in all three directions, is one of the key tools to look more closely into these issues but the huge amounts of data it produces make automated analysis necessary. State-of-the-art computer vision algorithms designed to operate on natural 2-D images tend to perform poorly when applied to EM data for a number of reasons. First, the sheer size of a typical EM volume renders most modern segmentation schemes intractable. Furthermore, most approaches ignore important shape cues, relying only on local statistics that easily become confused when confronted with noise and textures inherent in the data. Finally, the conventional assumption that strong image gradients always correspond to object boundaries is violated by the clutter of distracting membranes. In this work, we propose an automated graph partitioning scheme that addresses these issues. It reduces the computational complexity by operating on supervoxels instead of voxels, incorporates shape features capable of describing the 3-D shape of the target objects, and learns to recognize the distinctive appearance of true boundaries. Our experiments demonstrate that our approach is able to segment mitochondria at a performance level close to that of a human annotator, and outperforms a state-of-the-art 3-D segmentation technique.

While there has been substantial progress in segmenting natural images, state-of-the-art methods that perform well in such tasks unfortunately tend to underperform when confronted with the different challenges posed by electron microscope (EM) data. For example, in EM imagery of neural tissue, numerous cells and subcellular structures appear within a single image, they exhibit irregular shapes that cannot be easily modeled by standard techniques, and confusing textures clutter the background. We propose a fully automated approach that handles these challenges by using sophisticated cues that capture global shape and texture information, and by learning the specific appearance of object boundaries. We demonstrate that our approach significantly outperforms state-of-the-art techniques and closely matches the performance of human annotators.

Current procedures for the rapid inspection of buildings and infrastructure are subjective, time-consuming, and cumbersome to document, necessitating new technologies to automate the process and eliminate these shortcomings. Fortunately, recent developments in imaging devices and artificial intelligence, such as computer vision, provide the necessary tools for this, though they are not yet integrated into infrastructure applications. In this paper, we propose an end-to-end pipeline that generates damage-augmented digital twins for buildings at LOD3, including geometrical information as well as data pertaining to damage condition and its characterization. Our framework incorporates multiple-view images to (1) create a level of detail model, (2) segment damage information, and (3) characterize damage. The core of the method is the structure from motion, which is used to reconstruct the building scene, and machine-learning models that segment and characterize damage. In contrast to current practices, our method does not require manual intervention, generates lightweight models, and can be applied to a wide range of assets. The results generated with our pipeline represent a significant step towards an automated infrastructure damage assessment. We intend to expand our work in the future to include real-time applications and applications to other types of infrastructure. Codes and data sets are publicly available (https://github.com/eesd-epfl/DADT%5fbuildings and https://doi.org/10.5281/zenodo.7767478). • A novel framework to generate Damage Augmented Digital Twins (DADT) of buildings. • State-of-the-art solutions for 3D models, crack segmentation and characterization. • Bench-marking data set for evaluating the automated generation of DADT of buildings. [ABSTRACT FROM AUTHOR]