1. Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children’s hospitals demonstrates improved clinical outcomes and reduced costs of care
- Author
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Christina Ashburner, Arthur D’Harlingue, Rosanna Spicer, Suma P. Shankar, Shimul Chowdhury, Juliette Hunt, David Dimmock, Katarzyna A. Ellsworth, Neda Zadeh, Bryce Waldman, Lauge Farnaes, Wendy Benson, Madelena Martin, Jason Knight, Sara A. Caylor, Ofelia Vargas-Shiraishi, Aaina Kochhar, Mario Augusto Rojas, Charlotte A. Hobbs, Priscilla Joe, Katherine A. Rauen, Maries Joseph, Kathleen Houtchens, Richard Kronick, Ami Doshi, Adam Schwarz, Stephen F. Kingsmore, Carolina I. Galarreta, Jason Carmichael, Jolie Limon, Elaine Cham, Robert H. Kaplan, Jeanne Carroll, Kristen Wigby, and John P. Cleary
- Subjects
Male ,0301 basic medicine ,Comparative Effectiveness Research ,Quality management ,030105 genetics & heredity ,Medical and Health Sciences ,Tertiary care ,California ,quality improvement ,Cohort Studies ,Cost of Illness ,neonatal intensive care ,Prospective Studies ,Economic impact analysis ,Precision Medicine ,Genetics (clinical) ,Pediatric ,Genetics & Heredity ,Health Services ,Biological Sciences ,Hospitals, Pediatric ,Hospitals ,Treatment Outcome ,Female ,health outcomes research ,Medical emergency ,Critical Care ,pediatrics ,Critical Illness ,Clinical Trials and Supportive Activities ,Comparative effectiveness research ,rare disease ,QUALY ,Article ,03 medical and health sciences ,genetic disease ,Clinical Research ,Intensive care ,Genetics ,medicine ,Humans ,quality-adjusted life years ,Whole Genome Sequencing ,Medicaid ,business.industry ,Infant, Newborn ,Infant ,Newborn ,medicine.disease ,Precision medicine ,United States ,Quality-adjusted life year ,Good Health and Well Being ,030104 developmental biology ,MediCal ,real-world care ,business - Abstract
Genetic disorders are a leading contributor to mortality in neonatal and pediatric intensive care units (ICUs). Rapid whole-genome sequencing (rWGS)-based rapid precision medicine (RPM) is an intervention that has demonstrated improved clinical outcomes and reduced costs of care. However, the feasibility of broad clinical deployment has not been established. The objective of this study was to implement RPM based on rWGS and evaluate the clinical and economic impact of this implementation as a first line diagnostic test in the California Medicaid (Medi-Cal) program. Project Baby Bear was a payor funded, prospective, real-world quality improvement project in the regional ICUs of five tertiary care children's hospitals. Participation was limited to acutely ill Medi-Cal beneficiaries who were admitted November 2018 to May 2020, were
- Published
- 2021