1. Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
- Author
-
Saedah R. Al-Mhyawi, Rasha M. El Nashar, and Riham K. Ahmed
- Subjects
Detection limit ,voltammetry ,Materials science ,selective serotonin reuptake inhibitor ,Polymers and Plastics ,Scanning electron microscope ,poly (dl-methionine) ,Organic chemistry ,electropolymerization ,General Chemistry ,Electrochemistry ,Article ,Dielectric spectroscopy ,dl<%2Fspan>-methionine%29%22">poly (dl-methionine) ,QD241-441 ,Colloidal gold ,gold nanoparticles ,Differential pulse voltammetry ,Cyclic voltammetry ,Voltammetry ,Nuclear chemistry ,paroxetine - Abstract
This work demonstrates a facile electropolymerization of a dl-methionine (dl-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (dl-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10−11 to 5 × 10−8 M and from 5 × 10−8 to 1 × 10−4 M using DPV with lowest limit of detection (LOD = 1 × 10−11 M) based on (S/N = 3). The poly (dl-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively).
- Published
- 2021