1. Effects of Intensive Systolic Blood Pressure Control on All-Cause Hospitalizations
- Author
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Michael V. Rocco, Amret T. Hawfield, Miranda C. Marion, Carl D. Langefeld, Barry I. Freedman, and Mary E. Comeau
- Subjects
Male ,Blood pressure control ,medicine.medical_specialty ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Post-hoc analysis ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Intervention trial ,Antihypertensive Agents ,Aged ,business.industry ,Blood Pressure Determination ,Middle Aged ,Hospitalization ,Treatment Outcome ,Blood pressure ,Hypertension ,Cardiology ,Female ,business ,All cause mortality - Abstract
Intensive blood pressure control decreases the rate of cardiovascular events by >25% compared with standard blood pressure control. We sought to determine whether the decrease in cardiovascular events seen with intensive blood pressure control is associated with an increased rate of other causes of hospitalization. This is a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial) in 9361 adult participants with hypertension and elevated cardiovascular risk. Participants were randomly assigned to an intensive or standard systolic blood pressure goal (P =0.37). Equivalence testing shows that these hospitalization rates were statistically equivalent at the P =0.05 level. Of those with hospitalizations, >1 hospitalization was seen in 38.8% of intensive arm participants and 41.9% of standard arm participants ( P =0.08). The mean cumulative count of nonprimary event hospitalizations was comparable between the two arms. The most common causes of hospitalization were cardiovascular (23.6%) followed by injuries, including bone and joint therapeutic procedures (15.7%), infections (12.0%), and nervous systems disorders (10.7%). No categories of hospitalization were statistically more common in the intensive arm compared with the standard arm. Thus, the decrease in cardiovascular events seen with intensive blood pressure control is not associated with an increased rate of other causes of hospitalization. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01206062.
- Published
- 2020