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Inhibitory control is thought to play a key role in how bilinguals switch languages and may decline in aging. We tested these hypotheses by examining age group differences in the reversed language dominance effect-a signature of inhibition of the dominant language that leads bilinguals to name pictures more slowly in the dominant than the nondominant language in mixed-language testing blocks. Twenty-five older and 48 younger Spanish-English bilinguals completed a cued language-switching task. To test if inhibition is applied at the whole-language or lexical level, we first presented one set of pictures repeatedly, then introduced a second list halfway through the experiment. Younger bilinguals exhibited significantly greater reversed language dominance effects than older bilinguals (who exhibited nonsignificant language dominance effects). In younger bilinguals, dominance reversal transferred to, and was even larger in, the second list (compared to the first). The latter result may suggest that inhibition is partially offset by repetition in ways that are not yet fully understood. More generally, these results support the hypotheses that aging impairs inhibitory control of the dominant language, which young bilinguals rely on to switch languages. Additionally, inhibition is applied primarily at the whole-language level, and speculatively, this form of language control may be analogous to nonlinguistic proactive control. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

OBJECTIVE: Risk for memory decline is a common concern for individuals with temporal lobe epilepsy (TLE) undergoing surgery. Global and local network abnormalities are well-documented in TLE. However, it is less known whether network abnormalities predict post-surgical memory decline. We examined the role of pre-operative global and local white matter network organization in risk for post-operative memory decline in TLE. METHODS: One-hundred one individuals with TLE (51 left; L-TLE) and 56 controls underwent T1-weighted, diffusion-MRI and neuropsychological memory testing in a prospective longitudinal study. Forty-four patients subsequently underwent temporal lobe surgery and post-operative memory testing. Structural connectomes were generated via tractography and analyzed using measures of global (integration and specialization) and local (medial temporal lobe [MTL] specialization) network organization. RESULTS: Pre-operatively, higher global network integration and specialization were associated with higher verbal memory function in L-TLE. Higher pre-operative global network integration and specialization, as well as more leftward local specialization, predicted greater post-surgical verbal memory decline for L-TLE. Accounting for pre-operative memory score and hippocampal volume asymmetry, local network specialization additionally explained 25-33% of the variance in outcomes for L-TLE and outperformed hippocampal asymmetry. Local network specialization alone produced good diagnostic accuracy (AUC=.80-.84) in L-TLE. SIGNIFICANCE: Global white matter network disruption contributes to verbal memory impairment pre-operatively and predicts post-surgical memory outcomes in L-TLE. However, leftward asymmetry of MTL network organization confers the highest risk for memory decline. This demonstrates the importance of characterizing local network properties within the to-be-operated hemisphere and the reserve capacity of the contralateral MTL network.

Objective:The present study investigated the ability of the Multilingual Naming Test (MINT), a picture naming test recently added to the National Alzheimer’s Coordinating Center’s (NACC) Uniform Data Set neuropsychological test battery, to detect naming impairment (i.e., dysnomia) across stages of Alzheimer’s disease (AD).Method:Data from the initial administration of the MINT were obtained on NACC participants who were cognitively normal (N= 3,981) or diagnosed with mild cognitive impairment (N= 852) or dementia (N= 1,148) with presumed etiology of AD. Dementia severity was rated using the Clinical Dementia Rating (CDR) scale.Results:Cross-sectional multiple regression analyses revealed significant effects of diagnostic group, sex, education, age, and race on naming scores. Planned comparisons collapsing across age and education groups revealed significant group differences in naming scores across levels of dementia severity. ROC curve analyses showed good diagnostic accuracy of MINT scores for distinguishing cognitively normal controls from AD dementia, but not from MCI. Within the cognitively normal group, there was a robust interaction between age and education such that naming scores exhibited the most precipitous drop across age groups for the least educated participants. Additionally, education effects were stronger in African-Americans than in Whites (a race-by-education interaction), and race effects were stronger in older than in younger age groups (a race-by-age interaction).Conclusions:The MINT successfully detects naming deficits at different levels of cognitive impairment in patients with MCI or AD dementia, but comparison to age, sex, race, and education-corrected norms to determine impairment is essential.

Individuals with left temporal lobe epilepsy (TLE) have a higher rate of atypical (i.e., bilateral or right hemisphere) language lateralization compared to healthy controls. In addition, bilinguals have been observed to have a less left-lateralized pattern of language representation. We examined the combined influence of bilingual language experience and side of seizure focus on language lateralization profiles in TLE to determine whether bilingualism promotes re-organization of language networks. Seventy-two monolingual speakers of English (21 left TLE; LTLE, 22 right TLE; RTLE, 29 age-matched healthy controls; HC) and 24 English-dominant bilinguals (6 LTLE, 7 RTLE, 11 HC) completed a lexical-semantic functional MRI task and standardized measures of language in English. Language lateralization was determined using laterality indices based on activations in left vs right homologous perisylvian regions-of-interest (ROIs). In a fronto-temporal ROI, LTLE showed the expected pattern of weaker left language lateralization relative to HC, and monolinguals showed a trend of weaker left language lateralization relative to bilinguals. Importantly, these effects were qualified by a significant group by language status interaction, revealing that bilinguals with LTLE had greater rightward language lateralization relative to monolingual LTLE, with a large effect size particularly in the lateral temporal region. Rightward language lateralization was associated with better language scores in bilingual LTLE. These preliminary findings suggest a combined effect of bilingual language experience and a left hemisphere neurologic insult, which may together increase the likelihood of language re-organization to the right hemisphere. Our data underscore the need to consider bilingualism as an important factor contributing to language laterality in patients with TLE. Bilingualism may be neuroprotective pre-surgically and may mitigate post-surgical language decline following left anterior temporal lobectomy, which will be important to test in larger samples.

The current study investigated how Alzheimer’s disease (AD) affects production of speech errors in reading-aloud. Twelve Spanish-English bilinguals with AD and 19 matched controls read-aloud 8 paragraphs in four conditions (a) English-only, (b) Spanish-only, (c) English-mixed (mostly English with 6 Spanish words), and (d) Spanish-mixed (mostly Spanish with 6 English words). Reading elicited language intrusions (e.g., saying la instead of the), and several types of within-language errors (e.g., saying their instead of the). Patients produced more intrusions (and self-corrected less often) than controls, particularly when reading non-dominant language paragraphs with switches into the dominant language. Patients also produced more within-language errors than controls, but differences between groups for these were not consistently larger with dominant versus non-dominant language targets. These results illustrate the potential utility of speech errors for diagnosis of AD, suggest a variety of linguistic and executive control impairments in AD, and reveal multiple cognitive mechanisms needed to mix languages fluently. The observed pattern of deficits, and unique sensitivity of intrusions to AD in bilinguals, suggests intact ability to select a default language with contextual support, to rapidly translate and switch languages in production of connected speech, but impaired ability to monitor language membership while regulating inhibitory control.

Objective The current study investigated how Alzheimer's disease (AD) affects production of speech errors in reading-aloud of mixed-language passages with language switches on cognates (e.g., family/familia), noncognates (e.g., people/gente), and function words (the/la). Method Twelve Spanish-English bilinguals with AD and 22 controls read-aloud 8 paragraphs in 4 conditions: (a) English-default content switches, (b) English-default function switches, (c) Spanish-default content switches, and (d) Spanish-default function switches. Results Reading elicited language intrusions (e.g., saying la instead of the), and several types of within-language errors (e.g., saying their instead of the). Reversed language-dominance effects were intact in AD; both patients and controls produced many intrusions on dominant language targets, and relatively fewer intrusions on nondominant language targets. The opposite held for within-language errors, which were more common with nondominant than dominant targets. Patients produced the most intrusion errors with cognate switch words (which best distinguished patients from controls in ROC curves of all speech error types), while controls had equal difficulty switching on cognate and function word targets. Conclusions Reversed language-dominance effects appear to illustrate automatic inhibitory control over the dominant language, but could instead reflect limited resources available for monitoring when completing a task in the nondominant language. The greater sensitivity of intrusion errors with cognate than with function word targets for distinguishing patients from controls implies that language control may be aided by relatively intact knowledge of grammatical constraints over code-switching in bilinguals with AD. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

The current study examined the cognitive mechanisms underlying task and language switching by comparing them with each other, and with flanker task performance, at multiple points of the response time distribution. Ninety-eight Spanish-English bilinguals completed cued language and color-shape switching tasks, and 2 versions of a nonlinguistic flanker task. Bilinguals responded more quickly and exhibited smaller mixing costs in the language task, but surprisingly exhibited larger switching costs than in the color-shape task. This language-task disadvantage was especially apparent in slower reaction times (RTs), because switching costs increased significantly through the slowest end of the RT distribution only in the language task (but not in the color-shape task). Although the flanker task resembled the language task to a greater extent than the color-shape task in some measures (e.g., flanker effects were largest in the slowest RT bins, like language switching costs), in other measures the 2 switching tasks resembled each other and the flanker task stood out as different (i.e., trial sequence effects and correlations between tasks in various cost measures). These results reveal that different measures of switching costs even in tasks with very similar designs, vary in the extent to which they measure switching ability, both between tasks, and even between different trials within the same task. Distributional analysis of RTs across tasks suggests that slow responses, particularly when switching between non-naturally competing responses, might not measure switching ability at all, and raises the possibility that smaller switching costs can even reflect reduced ability to juggle tasks in some cases. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Tip-of-the-tongue (TOT) states often entail a phenomenological sense that retrieval is blocked, but incomplete activation is more commonly assumed as the underlying mechanism. Bilinguals have more TOTs than monolinguals, and commonly report that one language feels less accessible after immersion in another although evidence for this is minimal. Kreiner and Degani (2015) reported Russian-Hebrew bilinguals had more TOTs for Hebrew words after watching a movie in Russian, and surprisingly, native Hebrew speakers who did not know Russian also had more TOTs. Aiming to replicate this work, 72 Spanish-English bilinguals and 72 monolinguals completed a similar protocol in Experiment 1. Bilinguals and monolinguals exhibited significant and similarly sized interference effects after watching a Spanish movie. In Experiment 2, monolinguals completed five conditions: (a) Russian movie, (b) Spanish with English subtitles movie, (c) American Sign Language movie, (d) Spanish movie without audio and instructions to copy movements, and (e) a non-linguistic control (playing Tetris). All but the last two conditions elicited interference (increased TOTs and reduced correct retrievals). We suggest that even a brief pseudo-immersion experience can interfere with lexical-retrieval in the dominant language possibly via whole-language inhibition, supporting notions of blocked retrieval, albeit not at the level of individual lexical representations as previously proposed.

In the last decade, the debate about the causal role of the motor system in speech perception has been reignited by demonstrations that motor processes are engaged during the processing of speech sounds. However, the exact role of the motor system in auditory speech processing remains elusive. Here we evaluate which aspects of auditory speech processing are affected, and which are not, in a stroke patient with dysfunction of the speech motor system. The patient’s spontaneous speech was marked by frequent phonological/articulatory errors, and those errors were caused, at least in part, by motor-level impairments with speech production. We found that the patient showed a normal phonemic categorical boundary when discriminating two nonwords that differ by a minimal pair (e.g., ADA-AGA). However, using the same stimuli, the patient was unable to identify or label the nonword stimuli (using a button-press response). A control task showed that he could identify speech sounds by speaker gender, ruling out a general labeling impairment. These data suggest that the identification (i.e. labeling) of nonword speech sounds may involve the speech motor system, but that the perception of speech sounds (i.e., discrimination) does not require the motor system. This means that motor processes are not causally involved in perception of the speech signal, and suggest that the motor system may be used when other cues (e.g., meaning, context) are not available.

Bilingual language switching may increase general switching efficiency, but the evidence on this question is mixed. We hypothesized that group differences in switching might be stronger at a long cue-target interval (CTI), which may better tap general switching abilities (Yehene & Meiran, 2007). Eighty Spanish-English bilinguals and 80 monolinguals completed a color-shape switching task, and an analogous language-switching task, varying CTI (short vs. long) in both tasks. With longer preparation time (long CTI), bilinguals exhibited significantly smaller task-switching costs than monolinguals, but only in the first half of trials. Group differences diminished with practice, though practice benefitted RTs on short CTI trials more than long, and bilinguals committed fewer errors with practice especially at short CTI. Groups did not differ in mixing costs; however, across CTIs and tasks, bilinguals and monolinguals alike, exhibited robust correlations between mixing costs, but not between switching costs. These results confirm an association between bilingualism and switching efficiency that may be magnified with manipulations that target general switching ability (or could reflect better ability to take advantage of preparation time). However, practice effects observed within experimental paradigms, and between task correlations in costs, may reflect cognitive mechanisms specific to laboratory tasks much more than associations with general switching ability and executive control mechanisms-for which more reliable and valid measures can hopefully be developed in future work. (PsycINFO Database Record

Structural adaptations in brain regions involved in domain-general cognitive control are associated with life-long bilingualism and may contribute to the executive function advantage of bilinguals over monolinguals. To the degree that these adaptations support bilingualism, their disruption by Alzheimer's disease (AD) may compromise the ability to maintain proficiency in two languages, particularly in the less proficient, or nondominant, language that has greater control demands. The present study assessed this possibility in Spanish-English bilinguals with AD (n = 21) and cognitively normal controls (n = 30) by examining the brain correlates of dominant versus nondominant language performance on the Multilingual Naming Test (MINT), adjusting for age and education. There were no significant structural correlates of naming performance for either language in controls. In patients with AD, dominant language MINT performance was associated with cortical thickness of the entorhinal cortex and middle temporal gyrus, consistent with previous findings of temporal atrophy and related decline of naming abilities in AD. Nondominant language MINT performance, in contrast, was correlated with thickness of the left caudal anterior cingulate cortex (ACC), a central cognitive control region involved in error monitoring and task switching. The relationship between naming in the nondominant language and ACC in patients with AD but not in controls may reflect increased reliance on the ACC for nondominant language use in the face of atrophy of other control network components. The results are consistent with the possibility that the increased burden nondominant language use places on cognitive control systems compromised in AD may account for faster nondominant than dominant language decline in AD.

Motor theories of perception posit that motor information is necessary for successful recognition of actions. Perhaps the most well known of this class of proposals is the motor theory of speech perception, which argues that speech recognition is fundamentally a process of identifying the articulatory gestures (i.e. motor representations) that were used to produce the speech signal. Here we review neuropsychological evidence from patients with damage to the motor system, in the context of motor theories of perception applied to both manual actions and speech. Motor theories of perception predict that patients with motor impairments will have impairments for action recognition. Contrary to that prediction, the available neuropsychological evidence indicates that recognition can be spared despite profound impairments to production. These data falsify strong forms of the motor theory of perception, and frame new questions about the dynamical interactions that govern how information is exchanged between input and output systems.

Color is important in our daily interactions with objects, and plays a role in both low- and high-level visual processing. Previous neuropsychological studies have shown that color perception and object-color knowledge can doubly dissociate, and that both can dissociate from processing of object form. We present a case study of an individual who displayed an impairment for knowledge of the typical colors of objects, with preserved color perception and color naming. Our case also presented with a pattern of, if anything, worse performance for naming living items compared to non-living things. The findings of the experimental investigation are evaluated in light of two theories of conceptual organization in the brain: the Sensory/Functional Theory and the Domain-Specific Hypothesis. The dissociations observed in this case compel a model in which sensory/motor modality and semantic domain jointly constrain the organization of object knowledge.