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Background: Psoriasis (PS), psoriatic arthritis (PsA), and chronic periodontitis (CP) are the most common chronic inflammatory diseases and have remarkable pathologic similarities. The aim of this study is to investigate the effect of periodontal inflammation on oxidative stress in patients with PS and PsA by evaluating serum total antioxidant status, total oxidant status, oxidative stress index, levels of lipid hydroperoxides, and the activities of paraoxonase, arylesterase, and ceruloplasmin. Also measured were the levels of prolidase and total sulfhydryl groups.Methods: A total of 120 participants were divided into six groups of 20 participants: 1) PS with CP (PS-CP); 2) PS-periodontally healthy (PS-C); 3) PsA with CP (PsA-CP); 4) PsA-periodontally healthy (PsA-C); 5) systemically healthy with CP (CP); and 6) both systemically and periodontally healthy (C). Demographic, periodontal, and serum oxidative parameters were evaluated.Results: Oxidative stress index values of PS-C, PS-CP, PsA-C, and PsA-CP groups were approximately twice as high as those of C and CP groups, and there were no differences between any of the PS (PS-C and PS-CP), and PsA (PsA-C and PsA-CP) groups. Total antioxidant status levels of the C group were higher by 27% compared with those of the PS-C and the PsA-CP groups (P <0.05). Total oxidant status levels of both PsA-C and PsA-CP groups were approximately twice as high as those of the C (P <0.05) and CP (P <0.05, P <0.001 respectively) groups.Conclusions: The contribution of CP on systemic oxidative levels in patients with PS and PsA or systemically healthy individuals seems limited. PS and PsA did not show any additional detrimental effect on clinical parameters in patients with CP. [ABSTRACT FROM AUTHOR]

Granulomatosis with polyangiitis (GPA) is a primary systemic vasculitis characterized by granulomatous inflammation. Arthritis in GPA is most commonly associated with large joints, particularly the knees and ankles; however, symmetrical polyarthritis of small joints has been rarely reported in literature. Here, we describe retrospective analysis of six patients with GPA showing initial symptom of symmetrical polyarthritis who were followed-up by three different rheumatology departments. Male sex, anti-cyclic citrulinated peptide negativity, and early arthritis period are important clues for GPA. [ABSTRACT FROM AUTHOR]

Abstract: Objectives: There have been some studies on the burden of certain rheumatological disorders on the tendons; however, patients with familial Mediterranean fever (FMF) and Behçet''s disease (BD) have not, up to now, been studied in this regard in the literature. Thus, this current study centers on ensuing changes in the tendons of these patients. Methods: The study comprised 32 patients with FMF (13 male, 19 female), 31 with BD (18 male, 13 female) and 35 control subjects (17 male, 18 female). Sonographical evaluations were performed from the triceps, quadriceps and Achilles tendons on the non-dominant extremities of the individuals using a linear array probe of 8–16 MHz. Results: The mean triceps tendon (TT) thickness value of FMF patients was greater than that of BD patients (P =0.03) or the controls'' (P =0.02). The mean quadriceps tendon (QT) thickness value of BD patients was greater than that of FMF patients (P =0.00) or the controls'' (P =0.01). The mean Achilles tendon (AT) thickness value of BD patients was greater than that of controls'' (P =0.05) only. There was not any difference between the tendon thickness measurements of either group of patients with and without arthritic involvement. Conclusion: Our first and preliminary findings pertaining to increased tendon thicknesses in FMF (TT) and BD (QT and AT) patients should be complemented with future histological and clinical studies. The functional relevance of tendon thickening, its probable reflection on the rupture risk and the role of each disease related contributing factor remain to be uncovered. [Copyright &y& Elsevier]

Résumé: Objectifs: Contrairement à d''autres pathologies rhumatologiques, le retentissement de la maladie périodique et de la maladie de Behçet sur les tendons n''a pas été étudié jusqu''à présent dans la littérature. Le but de notre étude a donc été de rechercher des anomalies des tendons chez les patients atteints de ces maladies. Méthodes: Notre étude a été effectuée chez 32 malades (19 femmes et 13 hommes) atteints de maladie périodique, 31 malades (13 femmes et 18 hommes) atteints de maladie de Behçet et 35 sujets témoins sains (18 femmes et 17 hommes). L''évaluation échographique a porté sur les tendons du triceps, du quadriceps et le tendon d''Achille, du côté non dominant, à l''aide d''une sonde linéaire de 8 à 16 MHz de fréquence. Résultats: L''épaisseur moyenne du tendon du triceps était plus importante chez les malades atteints de maladie périodique par rapport à ceux atteints de maladie de Behçet (p =0,03) et par rapport aux témoins (p =0,02). L''épaisseur moyenne du tendon quadricipital était plus élevée chez les malades atteints de maladie de Behçet par rapport à ceux atteints de maladie périodique (p =0,00) et par rapport aux témoins (p =0,01). L''épaisseur moyenne du tendon d''Achille était plus importante chez les malades atteints de maladie de Behçet mais uniquement par rapport aux sujets témoins (p =0,05). Il n''a pas été observé de différence de l''épaisseur de ces tendons selon qu''il y ait ou non une atteinte articulaire et ce, dans chacun des groupes de malades. Conclusion: Ces résultats préliminaires indiquent une augmentation de l''épaisseur du tendon du triceps au cours de la maladie périodique et de celle du quadriceps et du tendon d''Achille au cours de la maladie de Behçet. Ils devraient être complétés à l''avenir par des études cliniques et histologiques. La signification fonctionnelle de l''épaississement tendineux, sa relation probable avec le risque de rupture, et le rôle physiopathologique de chacune de ces maladies dans ces anomalies reste à préciser. [Copyright &y& Elsevier]