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Objective To observe the curative effect of comprehensive rehabilitation therapy in the treatment of hemophilic chronic synovitis on the basis of conventional coagulation factor therapy. Methods A total of 92 patients with hemophilic chronic synovitis admitted to the Department of Rehabilitation Medicine of the hospital from August 2022 to February 2023 were selected. On the basis of on-demand treatment of coagulation factors, comprehensive rehabilitation treatment such as physical factor therapy and exercise therapy was performed for four weeks. The visual analogue pain scale, hemophilia joint health score, self-rating anxiety scale and self-rating depression scale were used to evaluate the changes of joint pain, joint activity, mood and mental health before and after treatment. Results Of the 92 patients, 90 completed the experiment and two with drew during there habilitation process. The scores of visual analogue pain scale, self-rating anxiety scale, self-rating depression scale and hemophilia joint health score of 90 patients after treatment were significantly lower than those before treatment, and the differences were statistically significant (P<0.05). Conclusion Comprehensive rehabilitation therapy can improve the pain symptoms and joint activity of patients with chronic synovitis of hemophilia, relieve their anxiety and depression, and improve their quality of life. [ABSTRACT FROM AUTHOR]