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Antiphospholipid syndrome is an autoimmune state of hypercoagulability caused by antibodies directed against the phospholipids of cell membranes. Objective: To describe the clinical and epidemiological characteristics of patients with a diagnosis of APS who attended in the university hospital A Price Lara. Materials and methods: Case series quantitative, descriptive, non-experimental and transversal research. Out of a population of 4636 medical records of patients, a sample of 45 medical records of patients with diagnosis of antiphospholipid syndrome was analyzed. Results: 100% of patients were female, mean age was 31.4 years old; 40 % were housewives, 13.33% secretary and another 13.33% dealer. 75.6% of patients were obstetric patients and the rest came from the rheumatology consult. The most frequent presentation was recurrent abortions in 80% of cases. Most frequent antiphospholipid syndrome was primary (68.9%) and one third of the cases required more than one type of medical treatment with low molecular weight heparin, warfarin or aspirin. Conclusion: Antiphospholipid syndrome is a disease with a wide range of clinical, immunological and epidemiological presentations that respnds to antithrombotic medication. [ABSTRACT FROM AUTHOR]