1. Cutaneous metastatic plasmacytomas with tropism for a previously injured limb.
- Author
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Pereira MA, Baudrier T, Costa A, Magalhães J, and Azevedo F
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy, Cyclophosphamide administration & dosage, Dexamethasone therapeutic use, Disease Progression, Fatal Outcome, Female, Fractures, Spontaneous etiology, Humans, Humeral Fractures etiology, Multiple Myeloma complications, Multiple Myeloma drug therapy, Multiple Myeloma pathology, Plasma Cells pathology, Plasmacytoma radiotherapy, Radiotherapy adverse effects, Skin Neoplasms drug therapy, Skin Neoplasms radiotherapy, Subcutaneous Tissue, Arm pathology, Plasmacytoma secondary, Skin Neoplasms secondary
- Abstract
Cutaneous plasmacytoma is an uncommon observation in clinical practice. It is usually a consequence of direct extension from an underlying bony lesion, in the setting of multiple myeloma. In our case, a 77-year-old woman, with stage IIIA IgG lambda multiple myeloma for two years, presented with firm nodular violaceous cutaneous lesions on the left arm without underlying bone osteolytic lesions or subcutaneous tumors; the biopsy was consistent with plasmacytoma. The patient had suffered two spontaneous left humeral fractures treated with prosthesis replacement just before the initial diagnosis of multiple myeloma. She had also been submitted to radiotherapy for a subcutaneous plasmacytoma, detected some months before, at the same site of the cutaneous lesions. Despite optimal response of the cutaneous lesions to treatment, the disease progressed and the patient died from infectious complications eight months after the appearance of the tumors.
- Published
- 2008