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The arid and semi-arid (ASA) region of Asia occupies a large area in the middle latitudes of the Northern Hemisphere, of which the main body is the ASA region of Central and East Asia (CEA). In this region, the climate is fragile and the environment is sensitive. The eastern part of the ASA region of CEA is located in the marginal zone of the East Asian monsoon and is jointly influenced by westerly circulation and the monsoon system, while in the western part of the ASA of CEA, the climate is mainly controlled by westerly circulation. To understand and predict the climate over this region, it is necessary to investigate the influence of general circulation on the climate system over the ASA region of CEA. In this paper, recent progress in understanding the relationship between the general circulation and climate change over the ASA region is systematically reviewed. Previous studies have demonstrated that atmospheric circulation represents a significant factor in climate change over the ASA region of CEA. In the years with a strong East Asian summer monsoon, the water vapor flux increases and precipitation is abundant in the southeastern part of Northwest China. The opposite situation occurs in years when the East Asian summer monsoon is weak. With the weakening of the East Asian summer monsoon, the climate tends to dry over the semi-arid region located in the monsoon marginal zone. Recently, owing to the strengthening of the South Asian monsoon, more water vapor has been transported to the ASA region of Asia. The Plateau summer monsoon intensity and the precipitation in summer exhibit a significant positive correlation in Central Asia but a negative correlation in North China and Mongolia. A significant positive correlation also exists between the westerly index and the temperature over the arid region of CEA. The change in the westerly circulation may be the main factor affecting precipitation over the arid region of Central Asia. [ABSTRACT FROM AUTHOR]