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This paper discusses the development trends of informatization in the function of the business change management in Croatian companies. This study is a review of the trends in development of informatization and factors of change management based on data collected from 50 large and medium-sized companies in Croatia. After analyzing the data, we systematized and analyzed factors of change management using complementary and comparative approach. The aim of the research is to systematize the factors of business change management, identify key factors and trends in strategic development of informatization of business systems, and analyze the modalities, the direction and intensity of the impact of trends in informatization on change management, by components (factors) and in a synergistic manner. In this paper we investigate the influence of strategic factors (trends) of development of business informatizaton on business change management factors to identify and systematize factors that promote alignment between business and IT strategy and factors of apps support to business system. The impact of strategic factors of informatization on business change management in Croatian companies has been investigated and presented using correlation-based techniques. The paper is structured in six interrelated parts. In the first section, the introduction, we discuss the features and trends in development of informatization as a function of business change management system. The second section discusses the features of computerized business in the example of Enterprise 2.0. In the third part, we systematize and describe the strategic characteristics of business system as factors of change management that define the level of shift from traditional to computerized operations. The fourth part presents and analyzes the results of the research of impact of strategic factors of business informatization on the factors of change management. In the fifth part, based on the results of research, we form and present a model of the impact of factors of business informatization on the factors of change management. A summary of the paper's main points has been included in the conlusion section.