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The Famatinian arc, over central-western Argentina, is one of the few examples of exposed crustal arc cross-section in the world. This Paleozoic magmatic arc and orogenic system on the Earth's surface offers unique insights into the nature of whole-arc processes, continental crust generation, and preservation. A detailed account of birth, growth, and closure is integrated throughout the region, and the entire geodynamic history of the Famatinian arc is presented. The Famatinian magmatic arc grew during a single-cycle episode that spanned a few tens of million years. Upon waning of the Cambrian Pampean orogen, an Upper Cambrian – Lower Ordovician marginal and open sea basin developed mostly on the recently stabilized Cambrian crystalline crust and was flooded by a turbidite wedge. Typical subduction zone magmatism resumed outboard of the Pampean orogen in the Lower Ordovician. After about 20 My of magmatism driven by subduction zone dynamics at plate scale, magmatism waned and stopped with the entry of a Laurentia-rifted continental microplate in the subduction zone. A full phase of a mountain-building process accompanied the continent-arc collision. The orogenic collapse occurred during the Devonian, ending the Famatinian system after nearly 150 My of magmatic arc, plate convergence, and continent-arc collision development on the proto-Andean Gondwana margin. • Geology shows a well-preserved Paleozoic magmatic arc and orogenic system on the Earth's surface. • A full plutonic crustal section formed in about 20 My of subduction-related magmatism. • A segment of Famatinian arc ended sandwiched between a Laurentian microplate and Gondwanan margin. • The subducting continental crust merged the overriding plutonic arc crust to make stable Continental Crust. [ABSTRACT FROM AUTHOR]