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The roots of Rauwolfia serpentine have some valuable properties like anti-hypertensive effect on consumption with its reserpine component as this root is the major source for reserpine alkaloid in evaluation with various herbs. In addition, the component ajmalicine is responsible in treating cardiovascular disease. The flowering plant Rauwolfia serpentine belongs to the family of Apocynaceae, found in Indian subcontinents or South Asia especially in India and mostly in places near to Himalayas. The studies reveal that it is commonly used in Unani Medicine as this system raised since 1037 AD one of the oldest medicinal practice, further the root of Rauwolfia serpentine used as a medicine to treat cardio vascular diseases was recorded 1000 years before in the manuscripts. The specialty of Rauwolfia serpentine is the alkaloids which are present in this plant are reserpine and ajmalicine which helps in assisting in curing the cardiovascular disease; it is also comprised with ajmaline that helps in treating atrial fibrillation and acute intravenous treatments. The in vitro analysis of Rauvolfia serpentine has evidences since the alkaloid found through phytochemical analysis are assisting in curing the cardiovascular disease and anxiety. [ABSTRACT FROM AUTHOR]