1. Isolated neonatal MRI punctate white matter lesions in very preterm neonates and quality of life at school age.
- Author
-
Arberet C, Proisy M, Fausser JL, Curt M, Bétrémieux P, Tréguier C, Rozel C, and Pladys P
- Subjects
- Adolescent, Brain diagnostic imaging, Child, Female, Follow-Up Studies, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Male, Apraxias epidemiology, Cerebral Palsy epidemiology, Leukoencephalopathies diagnostic imaging, Quality of Life, White Matter diagnostic imaging
- Abstract
Objective: To study the quality of life at school age of very preterm infants presenting isolated punctate periventricular white matter lesions (IPWL) on late-preterm or term magnetic resonance imaging (MRI)., Methods: In 1996-2000, 16 of the 131 very preterm neonates explored by MRI were found to have IPWL. At the age of 9-14, 12 children from the IPWL group were compared with 54 children born preterm but with a normal MRI (no lesion). Quality of life (Health Status Classification System Pre School questionnaire), school performance, and motor outcome were investigated., Results: Overall quality of life did not differ between the groups (classified as perfect in 2/12 of the IPWL vs 20/54 in the no-lesion). The sub-items mobility and dexterity differed significantly between the two groups, with impairment in the IPWL group (p < 0.001 and p < 0.05). This group also displayed higher levels of motor impairment: they began walking later [20(4) vs. 15(3) months), p < 0.01], had higher frequencies of cerebral palsy (6/12 vs. 2/54, p < 0.05), and dyspraxia (4/12 vs. 0/54, p < 0.001). The rate of grade retention did not differ between the groups (3/12 in the IPWL group vs. 17/54 in the no-lesions group) but, as expected, was higher than that of the French general population (17.4%) during the study period., Conclusion: This long-term follow-up study detected no increase in the risk of subsequent cognitive impairment in very preterm infants with IPWL, but suggests that these children may have a significantly higher risk of dyspraxia, and motor impairment. more...
- Published
- 2017
- Full Text
- View/download PDF