1. Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia
- Author
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Bence G. Márkus, I. Gresits, Gy. Thuróczy, B. Gyüre-Garami, O. Sági, and Ferenc Simon
- Subjects
Hyperthermia ,Hot Temperature ,Materials science ,Radio Waves ,Science ,FOS: Physical sciences ,Solenoid ,Applied Physics (physics.app-ph) ,02 engineering and technology ,Calorimetry ,01 natural sciences ,Article ,Magnetics ,Resonator ,Quality (physics) ,Neoplasms ,0103 physical sciences ,medicine ,Humans ,Irradiation ,Magnetite Nanoparticles ,010302 applied physics ,Multidisciplinary ,Equipment Design ,Hyperthermia, Induced ,Physics - Applied Physics ,021001 nanoscience & nanotechnology ,medicine.disease ,Magnetic Resonance Imaging ,Physics - Medical Physics ,Equipment Failure Analysis ,Electromagnetic coil ,Medicine ,Medical Physics (physics.med-ph) ,Radio frequency ,0210 nano-technology ,Biomedical engineering - Abstract
Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measurement. We present the validation for two types of resonators with very different filling factors: a solenoid and a so-called birdcage coil. The latter is a volume coil, which is generally used in magnetic resonance imaging (MRI) under in vivo condition. The presented method therefore allows to effectively combine MRI and thermotherapy and is thus readily adaptable to existing imaging hardware., 7 pages, 3 figures+Supplementary Material (2 pages, 3 figures)
- Published
- 2018