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Start Over Author "Zúñiga-Toalá A" Topic apoptosis
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1. Nordihydroguaiaretic acid induces Nrf2 nuclear translocation in vivo and attenuates renal damage and apoptosis in the ischemia and reperfusion model.

Author

Zúñiga-Toalá A, Zatarain-Barrón ZL, Hernández-Pando R, Negrette-Guzmán M, Huerta-Yepez S, Torres I, Pinzón E, Tapia E, and Pedraza-Chaverri J

Subjects
Acute Kidney Injury pathology, Animals, Disease Models, Animal, Drug Evaluation, Preclinical, Male, Masoprocol therapeutic use, Rats, Rats, Wistar, Reperfusion Injury pathology, Acute Kidney Injury prevention & control, Apoptosis drug effects, Masoprocol pharmacology, NF-E2-Related Factor 2 metabolism, Nuclear Localization Signals biosynthesis, Reperfusion Injury prevention & control
Abstract

It has been shown that the pretreatment with nordihydroguaiaretic acid (NDGA), a lignan with direct and indirect antioxidant properties, protects against the ischemia-reperfusion (I/R)-induced renal oxidant damage. Although it has been shown that NDGA induces Nrf2 nuclear translocation in renal epithelial LLC-PK1 cells in culture, it is unknown if NDGA may induce Nrf2 translocation in vivo. In this work was explored if NDGA is able to induce in vivo Nrf2 nuclear translocation in kidneys of rats submitted to uni-nephrectomy (U-NX) or I/R injury. Four groups of male Wistar rats were used: U-NX, NDGA, I/R, and I/R+NDGA. NDGA was injected i.p. (10mg/kg/day) starting 48 h before I/R. Kidney samples were obtained at 3 h of reperfusion after to measure Nrf2 translocation. Additional groups of rats were studied at 24 h of reperfusion to measure histological damage and apoptosis. NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis. It is concluded that the pretreatment of NDGA is able to induce in vivo nuclear Nrf2 translocation in kidney of rats suggesting that this may be involved in the renoprotection against I/R., (Copyright © 2013 Elsevier GmbH. All rights reserved.)

Published
2013
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2. Nordihydroguaiaretic acid induces Nrf2 nuclear translocation in vivo and attenuates renal damage and apoptosis in the ischemia and reperfusion model

Author

Adverqueydi Zúñiga-Toalá, Enrique Pinzón, José Pedraza-Chaverri, Sara Huerta-Yepez, Mario Negrette-Guzmán, Zyanya Lucía Zatarain-Barrón, Ismael Torres, Edilia Tapia, and Rogelio Hernández-Pando

Subjects
Male, NF-E2-Related Factor 2, Nuclear Localization Signals, Drug Evaluation, Preclinical, Pharmaceutical Science, Chromosomal translocation, Apoptosis, Pharmacology, Biology, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Masoprocol, Rats, Wistar, Kidney, Acute kidney injury, respiratory system, Acute Kidney Injury, medicine.disease, Rats, Nordihydroguaiaretic acid, Disease Models, Animal, medicine.anatomical_structure, Complementary and alternative medicine, chemistry, Biochemistry, Reperfusion Injury, Molecular Medicine, Reperfusion injury, medicine.drug
Abstract

It has been shown that the pretreatment with nordihydroguaiaretic acid (NDGA), a lignan with direct and indirect antioxidant properties, protects against the ischemia-reperfusion (I/R)-induced renal oxidant damage. Although it has been shown that NDGA induces Nrf2 nuclear translocation in renal epithelial LLC-PK1 cells in culture, it is unknown if NDGA may induce Nrf2 translocation in vivo. In this work was explored if NDGA is able to induce in vivo Nrf2 nuclear translocation in kidneys of rats submitted to uni-nephrectomy (U-NX) or I/R injury. Four groups of male Wistar rats were used: U-NX, NDGA, I/R, and I/R+NDGA. NDGA was injected i.p. (10mg/kg/day) starting 48 h before I/R. Kidney samples were obtained at 3 h of reperfusion after to measure Nrf2 translocation. Additional groups of rats were studied at 24 h of reperfusion to measure histological damage and apoptosis. NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis. It is concluded that the pretreatment of NDGA is able to induce in vivo nuclear Nrf2 translocation in kidney of rats suggesting that this may be involved in the renoprotection against I/R.

Published
2012

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