1. UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
- Author
-
Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, and Hinck L
- Subjects
- Animals, Mice, Mice, Knockout, Nerve Growth Factors genetics, Netrin Receptors, Netrin-1, Neurons pathology, Receptors, Cell Surface genetics, Spinal Cord abnormalities, Spinal Cord metabolism, Tumor Suppressor Proteins genetics, Apoptosis physiology, Nerve Growth Factors metabolism, Neurons metabolism, Receptors, Cell Surface metabolism, Spinal Cord cytology, Spinal Cord embryology, Tumor Suppressor Proteins metabolism
- Abstract
In addition to their role as chemorepellent netrin-1 receptors, UNC5 proteins may mediate cell death because they induce apoptosis in cultured cells. To test this in vivo, we generated Unc5a (formerly Unc5h1) knockout mice and found that this deletion decreased apoptosis and increased the number of neurons in the spinal cord. In contrast, loss of netrin-1 (Ntn1) did not affect the amount of apoptosis, suggesting that NTN1 is not required for neuronal apoptosis in vivo.
- Published
- 2006
- Full Text
- View/download PDF