1. Apoptosis Disorder, a Key Pathogenesis of HCMV-Related Diseases.
- Author
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Yu Z, Wang Y, Liu L, Zhang X, Jiang S, and Wang B
- Subjects
- Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections therapy, Cytomegalovirus Infections virology, Humans, Models, Biological, Prevalence, Signal Transduction, Apoptosis, Cytomegalovirus physiology, Cytomegalovirus Infections pathology
- Abstract
Human cytomegalovirus (HCMV) belongs to the β-herpesvirus family, which is transmitted in almost every part of the world and is carried by more than 90% of the general population. Increasing evidence indicates that HCMV infection triggers numerous diseases by disrupting the normal physiological activity of host cells, particularly apoptosis. Apoptosis disorder plays a key role in the initiation and development of multiple diseases. However, the relationship and molecular mechanism of HCMV-related diseases and apoptosis have not yet been systematically summarized. This review aims to summarize the role of apoptosis in HCMV-related diseases and provide an insight into the molecular mechanism of apoptosis induced by HCMV infection. We summarize the literature on HCMV-related diseases and suggest novel strategies for HCMV treatment by regulating apoptosis.
- Published
- 2021
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