1. Synthesis of novel spirostanic saponins and their cytotoxic activity.
- Author
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Hernández JC, León F, Brouard I, Torres F, Rubio S, Quintana J, Estévez F, and Bermejo J
- Subjects
- Antineoplastic Agents pharmacology, Caspase 9, Cell Cycle drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Cytochromes c, Drug Screening Assays, Antitumor, HL-60 Cells, Humans, Melanoma, Saponins chemical synthesis, U937 Cells, Antineoplastic Agents chemical synthesis, Apoptosis drug effects, Saponins pharmacology
- Abstract
This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.
- Published
- 2008
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