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1. [1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum.

Author

Dos S Beirigo PJ, Torquato HF, Dos Santos CH, Carvalho MG, Castro RN, Paredes-Gamero EJ, de Sousa PT Jr, Jacinto MJ, and da Silva VC

Subjects
Brazil, DNA analysis, Humans, Jurkat Cells, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Peptides, Cyclic chemistry, Peptides, Cyclic pharmacology, Apoptosis drug effects, Peptides, Cyclic isolation & purification, Plant Leaves chemistry, Zanthoxylum chemistry
Abstract

A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).

Published
2016
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