4 results on '"Corrêa, Cristiane Bani"'
Search Results
2. Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell
- Author
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de Franca, Mariana Nobre Farias, Isidório, Raquel Geralda, Bonifacio, João Henrique Oliveira, dos Santos, Edmilson Willian Propheta, Santos, Jileno Ferreira, Ottoni, Flaviano Melo, de Lucca Junior, Waldecy, Scher, Ricardo, Alves, Ricardo José, and Corrêa, Cristiane Bani
- Published
- 2021
- Full Text
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3. Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells.
- Author
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dos Santos, Edmilson Willian Propheta, de Sousa, Rauan Cruz, de Franca, Mariana Nobre Farias, Santos, Jileno Ferreira, Ottoni, Flaviano Melo, Isidório, Raquel Geralda, de Lucca Junior, Waldecy, Alves, Ricardo José, Scher, Ricardo, and Corrêa, Cristiane Bani
- Subjects
PHYTOTHERAPY ,THERAPEUTIC use of antineoplastic agents ,ADENOCARCINOMA ,LUNG cancer ,QUINONE ,WOUND healing ,FLOW cytometry ,STAINS & staining (Microscopy) ,ANALYSIS of variance ,COLONY-forming units assay ,HEMOLYSIS & hemolysins ,ANTINEOPLASTIC agents ,APOPTOSIS ,CELL motility ,LEAVES ,CELL lines ,PLANT extracts ,MOLECULAR structure ,ERYTHROCYTES ,DATA analysis software ,NECROSIS ,CELL death ,PHARMACODYNAMICS - Abstract
Background: Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a high cytotoxic effect in cancer cell lines and its derivatives show an even higher cytotoxic effect. Methods: Sulforhodamine B was used to evaluate the cytotoxic activity of compounds on tumor cells. Clonogenic assay was used to analyze the reduction of colonies and wound healing assay to the migratory capacity of A549 cells. Apoptosis and necrosis were analyzed by flow cytometer and Giemsa staining. Hemolysis assay to determine toxicity in human erythrocytes. Results: Lawsone derivatives were evaluated and compound 1 (O-propargyllawsone) was the one with the highest cytotoxic effect, with IC
50 below 2.5 µM in A549 cells. The compound was able to reduce colony formation and inhibit cell migration. Morphological changes and cytometry analysis show that the compound induces apoptosis and necrosis in A549 cells. Conclusions: These results show that O-propargyllawsone show a cytotoxic effect and may induce apoptosis in A549 cells. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
4. Anti-proliferative and pro-apoptotic effect of lawsone derivatives on melanoma cells
- Author
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Franca, Mariana Nobre Farias de, Corrêa, Cristiane Bani, and Scher, Ricardo
- Subjects
Citotoxicidade ,CIENCIAS DA SAUDE ,Célula tumoral ,Apoptose ,Tumor cell ,Cytotoxicity ,Health Sciences ,Apoptosis ,Lawsona ,Melanoma ,Ciências da saúde ,Lausona - Abstract
Cancer affects millions of people worldwide and is responsible for 8.8 million deaths per year. Among the skin-type cancer, melanoma is the most aggressive and it was responsible for more than 50.000 deaths in 2020. The impact caused by this disease reveals the importance of research for new molecules with more effective antitumor activity. Natural products are an important source of bioactive molecules, and lawsone, naphthoquinone widely studied, is an important source of molecules with cytotoxic activity. In this context, the study aimed to evaluate the cytotoxic effect of galactoside derivative of lausona in melanoma cells. For this, the degree of inhibition of cell proliferation (GI) of 16 lawsone derivatives was evaluated against three tumor cell lines: lung carcinoma (A549), melanoma (B16F10) and glioma (C6), by the Sulforrodamine B assay. Seven compounds (1, 9, 10, 11, 13, 14 and 15) showed a degree of inhibition greater than 75% in the three cells studied. According to the chemical characteristics of molecule 9, such as the presence of triazole ring and galactose, and the low IC50 (5.3 μM) obtained in 72 h of treatment, this molecule was selected for the next tests in the B16F10 cells. The clonogenic assay showed that the molecule reduced the formation of melanoma colonies. In addition, morphological changes of the melanoma lineage were observed by staing with DAPI and Faloidin/FITC. In this analysis, apoptotic changes were evidenced, in addition to cytoplasmic reduction with changes in the disposition of actin fibers, and loss of cellular conformation in relation to control. These results corroborate flow cytometry, in which showed apoptotic (Annexin positive) and necrosis (PI positive) cell were evaluated, with a percentage increase in apoptosis cells after treatment. The results presented in this work reveal an important active potential of compound 9, derived from lawsone, on tumor cells. O câncer atinge milhões de pessoas no mundo e é responsável por 8,8 milhões de mortes por ano. Dentre os cânceres que acometem a pele, o melanoma é o mais agressivo e foi responsável por mais de 50.000 mortes em 2020. O impacto causado por essa doença revela a importância de pesquisas por novas moléculas com atividade antitumoral mais efetiva. Produtos naturais são uma importante fonte de moléculas bioativas, e a lausona, naftoquinona amplamente estudada, é uma importante fonte de moléculas com atividade citotóxica. Neste contexto, o objetivo desse estudo foi avaliar o efeito citotóxico de derivados de lausona em linhagem de melanoma. Para isso, foi avaliado o grau de inibição da proliferação celular (GI) de 16 moléculas derivadas de lausona frente a três linhagens de células tumorais: carcinoma de pulmão (A549), melanoma (B16F10) e glioma (C6), pelo ensaio de Sulforrodamina B. Sete compostos (1, 9, 10, 11, 13, 14 e 15) apresentaram grau de inibição maior que 75% nas três linhagens estudadas. De acordo com as características químicas da molécula 9, tais como, presença de anel triazol e galactose, e a baixa CI50 (5,3 μM) obtida em 72 h de tratamento, esta molécula foi selecionada para os próximos ensaios na linhagem B16F10. O ensaio clonogênico mostrou que a molécula reduziu a formação de colônias de melanoma. Além disso, foram observadas alterações morfológicas da linhagem de melanoma pela marcação com DAPI e Faloidina/FITC. Nessa análise foi evidenciado alterações características de apoptose, além da redução citoplasmática com alterações na disposição dos filamentos de actina, e perda da conformação celular em relação ao controle. Esses resultados corroboram a citometria de fluxo, na qual foram avaliadas as células em apoptose (Anexina positivas) e necrose (PI positivas), com aumento percentual de células em apoptose após tratamento. Com base nesses resultados, pode-se concluir que o derivado de lausona 9 apresenta um importante potencial citotóxico com atividade mediada por sua característica pró-apoptótica em células de melanoma. Aracaju
- Published
- 2021
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