1. Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions.
- Author
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Cao S, Liu P, Zhu H, Gong H, Yao J, Sun Y, Geng G, Wang T, Feng S, Han M, Zhou J, and Xu Y
- Subjects
- Actins genetics, Actins immunology, Apoptosis drug effects, Caspase 3 genetics, Caspase 3 immunology, Chemotaxis drug effects, Escherichia coli immunology, Gene Expression Regulation, Humans, Hydrogen-Ion Concentration, Immunity, Innate, N-Formylmethionine Leucyl-Phenylalanine pharmacology, Neutrophils cytology, Neutrophils drug effects, Phagocytosis drug effects, Phosphorylation, Primary Cell Culture, Proto-Oncogene Proteins c-akt genetics, Proto-Oncogene Proteins c-akt immunology, Reactive Oxygen Species immunology, Reactive Oxygen Species metabolism, Respiratory Burst drug effects, Signal Transduction, Apoptosis immunology, Chemotaxis immunology, Neutrophils immunology, Respiratory Burst immunology
- Abstract
In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.
- Published
- 2015
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