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Start Over Author "Canu S" Topic apoptosis
3 results on '"Canu S"'

1. Cell sex: a new look at cell fate studies.

Author

Maselli A, Matarrese P, Straface E, Canu S, Franconi F, and Malorni W

Subjects
Animals, Cell Death physiology, Cell Line, Cell Line, Tumor, Cells pathology, Female, Germ Cells, Gonadal Hormones physiology, Humans, Male, Models, Biological, Necrosis, Oxidative Stress physiology, Reactive Oxygen Species metabolism, Sex Factors, Apoptosis physiology, Cells drug effects, Gonadal Hormones pharmacology, Oxidative Stress drug effects
Abstract

Cell death processes have been widely investigated in recent years in order to elucidate the different pathways involved in the complex machinery implicated in determining cell fate. Different forms of cell death have been described: Apart from the classical form of death known as necrosis, a well-characterized traumatic injury of the cell, several additional forms of cell death have been identified. Of these, apoptosis has been characterized in the greatest detail. Defects in the mechanisms of cell demise (that is, an excess of or decrease in apoptosis) have been associated with the pathogenesis of a number of human diseases. Here we review some new aspects derived from recent insights into this field, particularly the hypothesis that cells of males and females could display several different features, including those determining their fate.

Published
2009
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2. Cell sex determines anoikis resistance in vascular smooth muscle cells

Author

Rosa Vona, Lucrezia Gambardella, Maria Marino, Silvia Canu, Paola Bulzomi, Flavia Franconi, Rita Coinu, Giuseppe M.C. Rosano, Barbara Ascione, Walter Malorni, Elisabetta Straface, Straface, E, Vona, R, Gambardella, L, Ascione, B, Marino, Maria, Bulzomi, P, Canu, S, Coinu, R, Rosano, G, Malorni, W, and Franconi, F.

Subjects
Male, Vascular smooth muscle, Biophysics, Apoptosis, Biology, Senescence, Microfilament, Biochemistry, Muscle, Smooth, Vascular, Focal adhesion, Structural Biology, Vascular smooth muscle cells, Autophagy, Genetics, Cell Adhesion, Animals, Anoikis, Phosphorylation, Cytoskeleton, Cell adhesion, Molecular Biology, Actin, Sex Characteristics, Gender, Cell Biology, Actins, Cell biology, Rats, Female, Reactive oxygen species, Oxidation-Reduction
Abstract

Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.

Published
2009

3. Redox state and gender differences in vascular smooth muscle cells

Author

Paola Galluzzo, Flavia Franconi, Barbara Ascione, Elisabetta Straface, Paola Matarrese, Walter Malorni, Rita Coinu, Maria Marino, Silvia Canu, Malorni, W, Straface, E, Matarrese, P, Ascione, B, Coinu, R, Canu, S, Galluzzo, P, Marino, Maria, and Franconi, F.

Subjects
Senescence, Male, medicine.medical_specialty, Vascular smooth muscle, Blotting, Western, Myocytes, Smooth Muscle, Biophysics, Apoptosis, Biology, medicine.disease_cause, Biochemistry, Muscle, Smooth, Vascular, Superoxide dismutase, Structural Biology, Internal medicine, Vascular smooth muscle cells, Genetics, medicine, Animals, Cell Lineage, Annexin A5, Molecular Biology, Actin, Cellular Senescence, Cytoskeleton, chemistry.chemical_classification, Reactive oxygen species, Sex Characteristics, Gender, Cell Biology, Flow Cytometry, Actins, Rats, Endocrinology, chemistry, Microscopy, Fluorescence, Receptors, Estrogen, Receptors, Androgen, cardiovascular system, biology.protein, Female, Reactive Oxygen Species, Cell aging, Oxidation-Reduction, Oxidative stress, Propidium
Abstract

Vascular smooth muscle cells (VSMC) have been isolated from male and female rat aorta and studied to assess their susceptibility to ultraviolet radiation-induced oxidative stress. Interestingly, a gender difference, in terms of reactive oxygen species production, was detected in both basal and irradiated VSMC. Namely, VSMC from male rats were more susceptible to radiation-induced stress and easier underwent apoptosis in comparison to cells from female rats. Conversely, the latter, in the same experimental conditions, clearly displayed signs of premature senescence. These results indicate that a sort of “gender memory” can be conserved in VMSC in primary culture.

Published
2008

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