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1. RNAI advance: Liposome system delivers short RNAs that silence genes and reduce cholesterol

Author

Arnaud, Celia

Subjects
Alnylam Pharmaceuticals Inc. -- Research, Apolipoproteins -- Properties, Apolipoproteins -- Research, Monkeys -- Genetic aspects, Monkeys -- Research, Pharmaceutical industry -- Research, Chemicals, plastics and rubber industries, Engineering and manufacturing industries
Abstract

The gene-silencing technique called RNA interference has moved a step closer to becoming a viable therapeutic approach. Scientists at Alnylam Pharmaceuticals in Cambridge, used RNAi in monkeys to silence the gene for apolipoprotein B (ApoB), a protein involved in cholesterol metabolism, and it was observed that a single injection of a short interfering RNA reduced the level of ApoB gene in the liver.

Published
2006

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