1. Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis.
- Author
-
Liu ZW, Song M, Wang JY, Wang DZ, Sun B, Shi L, Jiang RW, Ma M, and Zhang XQ
- Subjects
- Monoterpenes analysis, Indole Alkaloids pharmacology, Indole Alkaloids analysis, Plant Leaves chemistry, Molecular Structure, Antineoplastic Agents, Apocynaceae chemistry, Secologanin Tryptamine Alkaloids pharmacology, Secologanin Tryptamine Alkaloids chemistry
- Abstract
Eight unprecedented monoterpenoid indole alkaloid (MIA) adducts and dimers, melofusinines A-H (1-8), and three undescribed melodinus-type MIA monomers, melofusinines I-K (9-11), together with six putative biogenetic precursors were isolated from the twigs and leaves of Melodinus fusiformis Champ. ex Benth. Compounds 1 and 2 are unusual hybrid indole alkaloids incorporating an aspidospermatan-type MIA with a monoterpenoid alkaloid unit via C-C coupling. Compounds 3-8 feature the first MIA dimers constructed through an aspidospermatan-type monomer and a rearranged melodinus-type monomer with two different types of couplings. Their structures were elucidated by spectroscopic data, single crystal X-ray diffraction, and calculated electric circular dichroism spectra analysis. In addition, dimers 5 and 8 showed significant neuroprotection effects on MPP
+ -injured primary cortical neurons., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF