1. Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor.
- Author
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Sunouchi K, Tsuru K, Maruta M, Kawachi G, Matsuya S, Terada Y, and Ishikawa K
- Subjects
- Apatites chemistry, Bone Substitutes chemistry, Calcium Carbonate chemistry, Porosity, Sodium Chloride chemistry, Apatites chemical synthesis, Bone Substitutes chemical synthesis, Microspheres
- Abstract
Spherical carbonate apatite (CO3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO3Ap microspheres with high uniformity could not be achieved without using a core. Solid CO3Ap microspheres were obtained using a calcite core whereas hollow CO3Ap microspheres were obtained using a NaCl core. The obtained microsphere was identified as B-type CO3Ap by Fourier transform infrared analysis and the carbonate content was approximately 7-8 wt% regardless of the type of core used for sample preparation. The mechanical strength of both the solid and hollow CO3Ap microspheres was sufficient for practical use as a bone substitute.
- Published
- 2012
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