1. Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.
- Author
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Liu O, Li J, Xin Y, Qin Y, Li H, Gong M, Liu Y, Wang X, Li J, and Zhang H
- Subjects
- Adult, Aged, Case-Control Studies, China ethnology, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Aortic Dissection genetics, Aortic Aneurysm, Thoracic genetics, Asian People genetics, Matrix Metalloproteinase 2 genetics
- Abstract
Background: Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population., Methods: In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression., Results: Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448)., Conclusions: MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.
- Published
- 2016
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