1. Extended 3D approach for quantification of abnormal ascending aortic flow
- Author
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Sigovan, M., Dyverfeldt, P., Wrenn, J., Tseng, E. E., Saloner, D., Hope, M. D., Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,Clinical Sciences ,Heart Valve Diseases ,Biomedical Engineering ,Cardiovascular ,Imaging ,Congenital ,Bicuspid Aortic Valve Disease ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Humans ,Aorta ,Heart Defects ,Aged ,Eccentric jets ,Aortic Valve Stenosis ,BAV ,Middle Aged ,Magnetic Resonance Imaging ,Valves ,Nuclear Medicine & Medical Imaging ,Aortic Valve ,Three-Dimensional ,Female ,Cognitive Sciences ,Blood Flow Velocity ,MRI - Abstract
BackgroundFlow displacement quantifies eccentric flow, a potential risk factor for aneurysms in the ascending aorta, but only at a single anatomic location. The aim of this study is to extend flow displacement analysis to 3D in patients with aortic and aortic valve pathologies.Methods43 individuals were studied with 4DFlow MRI in 6 groups: healthy, tricuspid aortic valve (TAV) with aortic stenosis (AS) but no dilatation, TAV with dilatation but no AS, and TAV with both AS and dilatation, BAV without AS or dilatation, BAV without AS but with dilation. The protocol was approved by our institutional review board, and informed consent was obtained. Flow displacement was calculated for multiple planes along the ascending aorta, and 2D and 3D analyses were compared.ResultsGood correlation was found between 2D flow displacement and both maximum and average 3D values (r>0.8). Healthy controls had significantly lower flow displacement values with all approaches (p
- Published
- 2015