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3 results on '"Sangyep Shin"'

1. Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus.

Author

Eu-Gene Kim, Wonseok Chang, SangYep Shin, Adhikari, Anjana Silwal, Geun Hee Seol, Dae-Yong Song, and Sun Seek Min

Subjects
GLUTAMATE decarboxylase, DENTATE gyrus, HIPPOCAMPUS (Brain), LIFE change events, ADOLESCENCE, GABAERGIC neurons
Abstract

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar disorder, and anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. It is used as an animal model for depression, and has well-known effects, such as increasing anxiety behavior and causing abnormalities in the hypothalamicpituitary-adrenal (HPA) axis. This study investigated the effect of MS on anxiety or aggression-like behavior and the number of GABAergic neurons in the hippocampus. Mice were separated from their dams for four hours per day for 19 d from postnatal day two. Elevated plus maze (EPM) test, resident-intruder (RI) test, and counted glutamic acid decarboxylase 67 (GAD67) or parvalbumin (PV) positive cells in the hippocampus were executed using immunohistochemistry. The maternal segregation group exhibited increased anxiety and aggression in the EPM test and the RI test. GAD67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, and parasubiculum. PVpositive neurons were increased in the DG, CA3, presubiculum, and parasubiculum. Consistent with behavioral changes, corticosterone was increased in the MS group, suggesting that the behavioral changes induced by MS were expressed through the effect on the HPA axis. Altogether, MS alters anxiety and aggression levels, possibly through alteration of cytoarchitecture and output of the ventral hippocampus that induces the dysfunction of the HPA axis. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Conditional Pten Knockout in Parvalbumin- or Somatostatin-positive Neurons Sufficiently Leads to Autism-related Behavioral Phenotypes

Author

Andrea Santi, Sangyep Shin, and Shiyong Huang

Subjects
0301 basic medicine, Repetitive behaviors, Autism, Anxiety, Motor Activity, Inhibitory postsynaptic potential, Motor deficits, lcsh:RC346-429, Mouse model, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, mental disorders, medicine, PTEN, Animals, Autistic Disorder, Social Behavior, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, Mice, Knockout, Neurons, biology, Behavior, Animal, Research, PTEN Phosphohydrolase, medicine.disease, Grooming, Pten, Mice, Inbred C57BL, 030104 developmental biology, Somatostatin, Parvalbumins, Phenotype, nervous system, Autism spectrum disorder, Social deficits, biology.protein, GABAergic, Psychopharmacology, Neuroscience, 030217 neurology & neurosurgery, Parvalbumin
Abstract

Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory neurons to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors in mice with conditional Pten knockout in parvalbumin (PV)-expressing or somatostatin (Sst)-expressing neurons, two common subtypes of GABAergic neurons. We found that mice with deletion of Pten in either PV-neurons or Sst-neurons displayed social deficits, repetitive behaviors and impaired motor coordination/learning. In addition, mice with one copy of Pten deletion in PV-neurons exhibited hyperlocomotion in novel open fields and home cages. We also examined anxiety behaviors and found that mice with Pten deletion in Sst-neurons displayed anxiety-like behaviors, while mice with Pten deletion in PV-neurons exhibited anxiolytic-like behaviors. These behavioral assessments demonstrate that Pten knockout in the subtype of inhibitory neurons sufficiently gives rise to ASD-core behaviors, providing evidence that both PV- and Sst-neurons may play a critical role in ASD symptoms.

Published
2020

3. Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

Author

Sangyep Shin, Andrea Santi, and Shiyong Huang

Subjects
Behavioral phenotypes, biology, medicine.disease, Inhibitory postsynaptic potential, Somatostatin, nervous system, Autism spectrum disorder, mental disorders, medicine, biology.protein, Autism, PTEN, Anxiety, medicine.symptom, Neuroscience, Parvalbumin
Abstract

Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory neurons to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors in mice with conditional Pten knockout in parvalbumin (PV)-expressing or somatostatin (Sst)-expressing neurons, two common subtypes of GABAergic neurons. We found that mice with deletion of Pten in either PV-neurons or Sst-neurons displayed social deficits, repetitive behaviors and impaired motor coordination/learning. In addition, mice with one copy of Pten deletion in PV-neurons exhibited hyperlocomotion in novel open fields and home cages. We also examined anxiety behaviors and found that mice with Pten deletion in Sst-neurons displayed anxiety-like behaviors, while mice with Pten deletion in PV-neurons exhibited anxiolytic-like behaviors. These behavioral assessments demonstrate that Pten knockout in the subtype of inhibitory neurons sufficiently gives rise to ASD-core behaviors, providing evidence that both PV- and Sst-neurons may play a critical role in ASD symptoms.

Published
2020
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