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Introduction: During the COVID-19 pandemic, the Albanian authorities declared mandatory stay-at-home measures, closing businesses, schools and public places. Objectives: To investigate the impact of these immediate changes on the mental wellbeing of the population. Methods: Respondents (N=1678) from 18 to 60 years old were selected through a convenient sampling method. Questionnaires were administered online reporting time spent daily in the COVID-19 topic and genealities; the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. Results: Findings suggest a significant negative correlation between age and anxiety scoring (r(n=1678)=-.121, p≤.001) and age and depression scoring (r(n=1678)=-.232, p≤.001), shown also on the ANOVA test for age and anxiety (F=6.019, p≤.05) and age and depression (F=20.326, p≤.05). Differences on the level of education resulted in a lower score of anxiety and depression respectively (F=3.524, p≤.05), (F=7.739, p≤.05) on respondents with higher education. Those who were jobless from the pandemic scored higher on anxiety and depression respectively (F=9.760, p≤.05) (M=6.21, ds=4.686) and (F=16.051, p≤.05) (M=8.18, ds=5.791). Significant differences were found related to different amounts of time spent on the COVID-19 topic, respectively for anxiety and depression (F=25.736, p≤.001), (F=5.936, p≤.003), with people who spend less than 1 hour scoring higher on depression (M=7.57, ds= 5.849) and those who spend more than 3 hours scoring higher on anxiety (M=6.76, ds=5.60). Conclusions: Higher education individuals, having a job and being in a romantic relationship relate to lower levels of depression during Covid-19 quarantine in Albania. Spending more time on the COVID-19 topic daily and being a female relate to higher level of anxiety. [ABSTRACT FROM AUTHOR]