1. In vitro interaction of eupomatenoid-5 from Piper solmsianum C. DC. var. solmsianum and anti-tuberculosis drugs.
- Author
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Lopes MA, Ferracioli KR, Siqueira VL, de Lima Scodro RB, Cortez DA, da Silva RZ, and Cardoso RF
- Subjects
- Antitubercular Agents isolation & purification, Benzofurans isolation & purification, Drug Resistance, Multiple, Bacterial, Drug Synergism, Ethambutol pharmacology, Genotype, Isoniazid pharmacology, Microbial Sensitivity Tests, Mycobacterium tuberculosis genetics, Phenols isolation & purification, Phytotherapy, Plant Extracts isolation & purification, Plant Leaves, Plants, Medicinal, Rifampin pharmacology, Antitubercular Agents pharmacology, Benzofurans pharmacology, Mycobacterium tuberculosis drug effects, Phenols pharmacology, Piper chemistry, Plant Extracts pharmacology
- Abstract
Setting: Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringa, Parana, Brazil., Objective: To evaluate the in vitro interaction between eupomatenoid-5 (EUP-5), extracted from Piper solmsianum C. DC. var. solmsianum, and first-line anti-tuberculosis drugs against Mycobacterium tuberculosis H₃₇Rv and 20 clinical isolates., Design: Resazurin drugs combination microtiter assay (REDCA) was performed to determine the interaction between EUP-5 and isoniazid, rifampicin (RMP) and ethambutol (EMB)., Results: Synergism was observed in M. tuberculosis H₃₇Rv and eight clinical isolates with EUP-5+RMP, and in M. tuberculosis H₃₇Rv and 17 clinical isolates with EUP-5+EMB combinations., Conclusion: EUP-5 is a promising compound for further studies on the development of anti-tuberculosis drugs.
- Published
- 2014
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