1. Effect of short course chemotherapy on salivary paracetamol elimination.
- Author
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Madhusudanarao K, Bapna JS, Adithan C, Ray K, Venkatadri N, Kamatchi GL, Seetharaman ML, and Bahadur P
- Subjects
- Adult, Drug Interactions, Half-Life, Humans, Male, Tuberculosis, Pulmonary drug therapy, Acetaminophen pharmacokinetics, Antitubercular Agents adverse effects, Saliva metabolism, Tuberculosis, Pulmonary metabolism
- Abstract
1. Salivary elimination of paracetamol was studied in six male pulmonary tuberculosis patients on short course chemotherapy. 2. Peak paracetamol concentration showed a steady decrease at the end of first week and continued until the end of the study. 3. The elimination half-life of paracetamol decreased 5 weeks after the therapy with a corresponding increase in the clearance rate. 4. Adjustment of dosage of drugs that are metabolized by the microsomal enzymes may be required in patients on anti-tubercular drug regimen in which rifampicin is included.
- Published
- 1988
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