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3 results on '"Donmez S"'

1. Epidemiology and outcome of adult-onset Still's disease in Northwestern Thrace region in Turkey.

Author

Balci MA, Pamuk ÖN, Pamuk GE, Uzundere FK, and Donmez S

Subjects
Adult, Demography, Female, Fever epidemiology, Fever etiology, Humans, Incidence, Male, Monitoring, Physiologic statistics & numerical data, Outcome Assessment, Health Care, Prevalence, Retrospective Studies, Turkey epidemiology, Antirheumatic Agents therapeutic use, Arthralgia epidemiology, Arthralgia etiology, Still's Disease, Adult-Onset complications, Still's Disease, Adult-Onset diagnosis, Still's Disease, Adult-Onset drug therapy, Still's Disease, Adult-Onset epidemiology
Abstract

Objectives: Adult-onset Still's disease (AOSD) is a rare disease that is classified among the multifactorial autoinflammatory disorders. It is characterised by fever, arthritis and, a typical salmon-coloured rash, and is accompanied by fever at nights. Currently, there is limited data on the prevalence of AOSD., Methods: Patients diagnosed with AOSD at the Department of Rheumatology of Trakya University Medical Faculty, between 2003 to 2014 were reviewed retrospectively. Patients' clinical features, laboratory measurements, demographics, treatments, follow-up durations, disease courses, outcomes and complications were evaluated., Results: Our study included 42 patients with AOSD of whom, 32 (76.2%) were females and 10 (23.8%) were males (female to male ratio: 3.2). Over the course of the study, the annual incidence of AOSD was 0.62/100,000; and the overall prevalence was 6.77/100,000. The most common findings were fever (97.6%), arthralgia (95.2%), arthritis (76.2%), rash (73.8%) and sore throat (40.5%)., Conclusions: In our hospital-based study on AOSD which is a disease with very limited epidemiological data, the frequency of AOSD was found to be significantly higher than in other series. Female gender was more common in our series; and polycyclic pattern was more common in patients with longer follow-ups.

Published
2015

2. Do impaired memory, cognitive dysfunction and distress play a role in methotrexate-related neutropenia in rheumatoid arthritis patients? A comparative study.

Author

Pamuk ON, Kisacik B, Pamuk GE, Onat AM, Sayarlioglu M, Donmez S, Pehlivan Y, and Keystone EC

Subjects
Adult, Aged, Aged, 80 and over, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid psychology, Cognition Disorders psychology, Female, Humans, Male, Memory Disorders psychology, Methotrexate therapeutic use, Middle Aged, Neutropenia chemically induced, Neutropenia psychology, Stress, Psychological psychology, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid drug therapy, Cognition Disorders complications, Memory Disorders complications, Methotrexate adverse effects, Neutropenia etiology, Stress, Psychological complications
Abstract

We evaluated the roles of sociocultural status, distress and cognitive functions in rheumatoid arthritis (RA) patients who developed methotrexate (MTX)-related neutropenia. The data of 37 RA patients with MTX-related neutropenia who were being followed up at 3 centers were evaluated. The control group included 74 RA patients. The clinical features, biochemical tests and treatment modalities of the patients were obtained from hospital files. The mini-mental state examination (MMSE) test and the Hospital Anxiety and Depression Scale (HADS) were administered for all RA patients with neutropenia as well as the control group. The frequencies of male patients, illiterate patients, patients living alone, patients with serious visual impairment, those with low income, and patients with high creatinine were significantly higher among RA patients with MTX-related neutropenia than in controls (p values <0.05). The RA patients with MTX-related neutropenia had significantly lower MMSE scores, and significantly higher HADS-A and HADS-D scores than controls (p values <0.05). In addition, the proportion of patients with probable dementia was significantly higher in RA patients with MTX-related neutropenia than in controls (p < 0.001). Twenty-six of the 37 patients (70.3 %) developed neutropenia with daily dosing. Patients who used MTX daily were more likely to be living alone than those using weekly dosing (p = 0.011). Multivariate analysis showed that having probable dementia on the MMSE test (OR 52.6), low income level (OR 56.8) and age (OR 1.12) were independent risk factors for the development of MTX-related neutropenia. The presence of probable dementia on MMSE, low socioeconomical status and older age are associated with serious toxicity in RA patients using MTX. Measures should be taken to prevent wrong MTX dosing by the patients. Compliance and patient education is of major importance, in particular, in the patients presented in this study.

Published
2013
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3. Diagnostic dilemma of paraneoplastic arthritis: Case series

Author

Kisacik, B, Onat, AM, Kasifoglu, T, Pehlivan, Y, Pamuk, ON, Dalkilic, E, Donmez, S, Bilge, SY, Yilmaz, S, Erdem, H, Mercan, R, Ozturk, MA, Bes, C, Soy, M, Erten, S, Cobankara, V, Senel, S, Oner, FA, Direskeneli, H, Yazici, A, Emmungil, H, Aksu, K, Kul, S, Cetin, GY, and Sayarlioglu, M

Subjects
Adult, Male, early rheumatoid arthritis, malignancy, paraneoplastic arthritis, Turkey, Paraneoplastic Syndromes, Early rheumatoid arthritis, Peptides, Cyclic, rheumatoid factor, Arthritis, Rheumatoid, immunology, Diagnosis, Differential, cyclopeptide, blood, Predictive Value of Tests, differential diagnosis, joint, middle aged, Humans, human, Aged, predictive value, L-Lactate Dehydrogenase, Arthritis, cyclic citrullinated peptide, Malignancy, lactate dehydrogenase, clinical trial, case control study, biological marker, Paraneoplastic arthritis, female, multicenter study, Treatment Outcome, Antirheumatic Agents, Case-Control Studies, antirheumatic agent, pathology, Biological Markers, Joints
Abstract

Objectives: Paraneoplastic arthritis (PA) may mimic rheumatic diseases. While presenting the demographic and laboratory features of the patients diagnosed with PA, this study also aims to provide possible appropriate tools to differentiate the PA cases from early rheumatoid arthritis (ERA). Methods: Sixty-five patients with PA (male/female: 43/22) from 15 different rheumatology clinics and 50 consecutive patients with ERA (male/female: 13/37) fulfilling the 2010 American College of Rheumatology (ACR) criteria for the diagnosis if the RA from Gaziantep Rheumatology Early Arthritis Trial (GREAT) as controls who were diagnosed at least 12 months before, were enrolled into study. Results: Mean ages of the patients with PA and ERA were 50.2 ± 15.3, and 42.7 ± 12.3, respectively, and the mean ages of the patients with PA were significantly higher than the ERA. Unlike the ERA patients, in our case series PA was predominantly observed among males. Oligoarthritis was significantly higher in solid tumors in contrast to ERA (P = 0.001). Polyarthritis and symmetric arthritis were significantly higher in the ERA group in contrast to all malignancies (P = 0.001). Rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) positivity were significantly higher in the ERA group (each P = 0.001). Lactic dehydrogenase levels of hematologic malignancies were significantly higher than other groups (each, P = 0.001). Conclusions: ERA patients had more symmetric joint involvement than PA; laboratory markers could be also an alternative where there is high RF and anti-CCP positivity with antibody levels among the ERA patients. Finally, the demographic features can be used as differentiating factors; ERA was seen predominantly among females aged 40-59 years which refers to young adults. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Published
2014

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