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Start Over Author "DiGiambenedetto S" Topic antiretroviral therapy, highly active
4 results on '"DiGiambenedetto S"'

2. Cohort Profile: Standardized Management of Antiretroviral Therapy Cohort (MASTER Cohort).

Author

Torti C, Raffetti E, Donato F, Castelli F, Maggiolo F, Angarano G, Mazzotta F, Gori A, Sighinolfi L, Pan A, Cauda R, Scalzini A, Quiros-Roldan E, Nasta P, Gregis G, Benatti S, Digiambenedetto S, Ladisa N, Giralda M, Saracino A, Castelnuovo F, Di Pietro M, Lo Caputo S, Lapadula G, Costarelli S, Lorenzotti S, Mazzini N, Paraninfo G, Casari S, Focà E, Pezzoli C, Fabbiani M, Monno L, Pierotti P, Ble C, Leone S, Postorino MC, Fornabaio C, Zacchi F, Zoncada A, and Carosi G

Subjects
Adult, Age Distribution, Aged, Antiretroviral Therapy, Highly Active adverse effects, Female, Humans, Italy epidemiology, Male, Middle Aged, Multicenter Studies as Topic, Prospective Studies, Retrospective Studies, Sex Distribution, Sustained Virologic Response, Young Adult, Antiretroviral Therapy, Highly Active methods, Drug Prescriptions statistics & numerical data, HIV Infections drug therapy, HIV Infections epidemiology
Published
2017
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3. Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy.

Author

Torti C, Prosperi M, Motta D, Digiambenedetto S, Maggiolo F, Paraninfo G, Ripamonti D, Cologni G, Fabbiani M, Caputo SL, Sighinolfi L, Ladisa N, El-Hamad I, Quiros-Roldan E, and Frank I

Subjects
Adult, Anti-HIV Agents pharmacology, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes virology, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes virology, Female, HIV Infections mortality, HIV Infections virology, HIV-1 drug effects, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, RNA, Viral blood, Treatment Outcome, Viral Load, Anti-HIV Agents therapeutic use, Antiretroviral Therapy, Highly Active, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes immunology, HIV Infections drug therapy, HIV Infections immunology
Abstract

We evaluated factors associated with normalization of the absolute CD4+ T-cell counts, per cent CD4+ T cells and CD4+/CD8+ T-cell ratio. A multicentre observational study was carried out in patients with sustained HIV-RNA <50 copies/mL. Outcomes were: CD4-count >500/mm(3) and multiple T-cell marker recovery (MTMR), defined as CD4+ T cells >500/mm(3) plus%CD4 T cells >29%plus CD4+/CD8+ T-cell ratio >1. Kaplan-Meier survival analysis and Cox regression analyses to predict odds for achieving outcomes were performed. Three hundred and fifty-two patients were included and followed-up for a median of 4.1 (IQR 2.1-5.9) years, 270 (76.7%) achieving a CD4+ T-cell count >500 cells/mm(3) and 197 (56%) achieving MTMR. Using three separate Cox models for both outcomes we demonstrated that independent predictors were: both absolute CD4+ and CD8+ T-cell counts, %CD4+ T cells, a higher CD4+/CD8+ T-cell ratio, and age. A likelihood-ratio test showed significant improvements in fitness for the prediction of either CD4+ >500/mm(3) or MTMR by multivariable analysis when the other immune markers at baseline, besides the absolute CD4+ count alone, were considered. In addition to baseline absolute CD4+ T-cell counts, pretreatment %CD4+ T cells and the CD4+/CD8+ T-cell ratio influence recovery of T-cell markers, and their consideration should influence the decision to start antiretroviral therapy. However, owing to the small sample size, further studies are needed to confirm these results in relation to clinical endpoints., (© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.)

Published
2012
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4. Cohort Profile: Standardized Management of Antiretroviral Therapy Cohort (MASTER Cohort)

Author

Francesco Castelli, Maria Concetta Postorino, Silvia Lorenzotti, Gioacchino Angarano, Giampiero Carosi, Mariarosaria Giralda, Giuseppe Paraninfo, Nicola Mazzini, Fabio Zacchi, Elena Raffetti, Alessia Zoncada, Francesco Mazzotta, Roberto Cauda, Silvia Costarelli, Chiara Fornabaio, Eugenia Quiros-Roldan, Simona Digiambenedetto, Simone Benatti, Alfredo Scalzini, Emanuele Focà, Angelo Pan, Salvatore Casari, Massimo Di Pietro, Franco Maggiolo, Giampietro Gregis, Laura Monno, Filippo Castelnuovo, Paola Nasta, Sergio Lo Caputo, Piera Pierotti, Francesco Donato, Sebastiano Leone, Laura Sighinolfi, Carlo Torti, Massimiliano Fabbiani, Claudio Ble, Nicoletta Ladisa, Chiara Pezzoli, Annalisa Saracino, Andrea Gori, Giuseppe Lapadula, Torti, C, Raffetti, E, Donato, F, Castelli, F, Maggiolo, F, Angarano, G, Mazzotta, F, Gori, A, Sighinolfi, L, Pan, A, Cauda, R, Scalzini, A, Quiros-Roldan, E, Nasta, P, Gregis, G, Benatti, S, Digiambenedetto, S, Ladisa, N, Giralda, M, Saracino, A, Castelnuovo, F, Di Pietro, M, Lo Caputo, S, Lapadula, G, Costarelli, S, Lorenzotti, S, Mazzini, N, Paraninfo, G, Casari, S, Focà, E, Pezzoli, C, Fabbiani, M, Monno, L, Pierotti, P, Ble, C, Leone, S, Postorino, M, Fornabaio, C, Zacchi, F, Zoncada, A, and Carosi, G

Subjects
Adult, Male, medicine.medical_specialty, Sustained Virologic Response, Epidemiology, Alternative medicine, Human immunodeficiency virus (HIV), HIV Infections, hiv, medicine.disease_cause, Settore MED/17 - MALATTIE INFETTIVE, Drug Prescriptions, Young Adult, Age Distribution, Internal medicine, Antiretroviral Therapy, Highly Active, medicine, Humans, Multicenter Studies as Topic, Prospective Studies, Sex Distribution, Aged, Retrospective Studies, business.industry, Retrospective cohort study, General Medicine, Middle Aged, Antiretroviral therapy, Antiretroviral, Italy, Cohort, Female, Therapy, business
Published
2015

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